Activation of Ca2+/Calmodulin protein kinase II (CaMKII) is an important step in signaling of cardiac hypertrophy. The molecular mechanisms by which CaMKII integrates with other pathways in the heart are incompletely understood. We hypothesize that CaMKII association with extracellular regulated kinase (ERK), promotes cardiac hypertrophy through ERK nuclear localization.

Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy / Cipolletta, Ersilia; Rusciano, Maria Rosaria; Maione, Angela Serena; Santulli, Gaetano; Sorriento, Daniela; Del Giudice, Carmine; Ciccarelli, Michele; Franco, Antonietta; Crola, Catherine; Campiglia, Pietro; Sala, Marina; GOMEZ MONTERREY, ISABEL MARIA; DE LUCA, Nicola; Trimarco, Bruno; Iaccarino, Guido; Illario, Maddalena. - In: PLOS ONE. - ISSN 1932-6203. - 10:6(2015), p. e0130477. [10.1371/journal.pone.0130477]

Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy

SANTULLI, GAETANO;SORRIENTO, DANIELA;FRANCO, ANTONIETTA;GOMEZ MONTERREY, ISABEL MARIA;DE LUCA, NICOLA;TRIMARCO, BRUNO;Iaccarino, Guido;ILLARIO, MADDALENA
2015

Abstract

Activation of Ca2+/Calmodulin protein kinase II (CaMKII) is an important step in signaling of cardiac hypertrophy. The molecular mechanisms by which CaMKII integrates with other pathways in the heart are incompletely understood. We hypothesize that CaMKII association with extracellular regulated kinase (ERK), promotes cardiac hypertrophy through ERK nuclear localization.
2015
Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy / Cipolletta, Ersilia; Rusciano, Maria Rosaria; Maione, Angela Serena; Santulli, Gaetano; Sorriento, Daniela; Del Giudice, Carmine; Ciccarelli, Michele; Franco, Antonietta; Crola, Catherine; Campiglia, Pietro; Sala, Marina; GOMEZ MONTERREY, ISABEL MARIA; DE LUCA, Nicola; Trimarco, Bruno; Iaccarino, Guido; Illario, Maddalena. - In: PLOS ONE. - ISSN 1932-6203. - 10:6(2015), p. e0130477. [10.1371/journal.pone.0130477]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/613771
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 53
  • ???jsp.display-item.citation.isi??? 48
social impact