Epigenetic changes in DNA methylation could regulate the expression of several allergy-related genes. We investigated whether tolerance acquisition in children with immunoglobulin E (IgE)-mediated cow's milk allergy (CMA) is characterized by a specific DNA methylation profile of Th2 (IL-4, IL-5) and Th1 (IL-10, IFN-γ)-associated cytokine genes.

Differences in DNA methylation profile of Th1 and Th2 cytokine genes are associated with tolerance acquisition in children with IgE-mediated cow's milk allergy

BERNI CANANI, ROBERTO;PAPARO, LORELLA;NOCERINO, RITA;COSENZA, LINDA;DI COSTANZO, MARGHERITA;CAPASSO, Mario;DEL MONACO, VALENTINA;D'ARGENIO, VALERIA;GRECO, LUIGI;SALVATORE, FRANCESCO
2015

Abstract

Epigenetic changes in DNA methylation could regulate the expression of several allergy-related genes. We investigated whether tolerance acquisition in children with immunoglobulin E (IgE)-mediated cow's milk allergy (CMA) is characterized by a specific DNA methylation profile of Th2 (IL-4, IL-5) and Th1 (IL-10, IFN-γ)-associated cytokine genes.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/613577
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