Identification of single nucleotide polymorphisms in Toll-like receptor candidate genes associated with tuberculosis infection in water buffalo (Bubalus bubalis)

Alfano, Flora; Peletto, Simone; Lucibelli, Maria Gabriella; Borriello, Giorgia; Urciuolo, Giovanna; Maniaci, Maria Grazia; Desiato, Rosanna; Tarantino, Michela; Barone, Amalia; Pasquali, Paolo; Acutis, Pier Luigi; Galiero, Giorgio

doi:10.1186/s12863-014-0139-y

Toll-like receptors play a key role in innate immunity by recognizing pathogens and activating appropriate responses. Pathogens express several signal molecules (pathogen-associated molecular patterns, PAMPs) essential for survival and pathogenicity. Recognition of PAMPs triggers an array of anti-microbial immune responses through the induction of various inflammatory cytokines. The objective of this work was to perform a case-control study to characterize the distribution of polymorphisms in three candidate genes (toll-like receptor 2, toll-like receptor 4, toll-like receptor 9) and to test their role as potential risk factors for tuberculosis infection in water buffalo (Bubalus bubalis).

Titolo:	Identification of single nucleotide polymorphisms in Toll-like receptor candidate genes associated with tuberculosis infection in water buffalo (Bubalus bubalis)
Autori:	Alfano, Flora Peletto, Simone Lucibelli, Maria Gabriella Borriello, Giorgia Urciuolo, Giovanna Maniaci, Maria Grazia Desiato, Rosanna Tarantino, Michela BARONE, AMALIA Pasquali, Paolo Acutis, Pier Luigi Galiero, Giorgio mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2014
Rivista:	BMC GENETICS
Abstract:	Toll-like receptors play a key role in innate immunity by recognizing pathogens and activating appropriate responses. Pathogens express several signal molecules (pathogen-associated molecular patterns, PAMPs) essential for survival and pathogenicity. Recognition of PAMPs triggers an array of anti-microbial immune responses through the induction of various inflammatory cytokines. The objective of this work was to perform a case-control study to characterize the distribution of polymorphisms in three candidate genes (toll-like receptor 2, toll-like receptor 4, toll-like receptor 9) and to test their role as potential risk factors for tuberculosis infection in water buffalo (Bubalus bubalis).
Handle:	http://hdl.handle.net/11588/613150
Appare nelle tipologie:	1.1 Articolo in rivista

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http://hdl.handle.net/11588/613150

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