Herein, the synthesis of a nucleoside platinum(II) complex in which a cisplatin-like unit is joined to 7-deazaadenosine through an amino alkyl chain installed at the C6 position of purine was explored. The capability of the new complex to react with DNA purine bases was confirmed by a model reaction with deoxyguanosine monophosphate, whereas its antiproliferative activity against A549 and Cal27 human cancer cell lines was studied by sulforhodamine B assay in comparison with its unplatinated precursor and cisplatin.
Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin-Platinum(II) Complex / D'Errico, Stefano; Oliviero, Giorgia; Borbone, Nicola; Di Gennaro, Elena; Zotti, Andrea Ilaria; Budillon, Alfredo; Cerullo, Vincenzo; Nici, Fabrizia; Mayol, Luciano; Piccialli, Vincenzo; Piccialli, Gennaro. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - (2015), pp. 7550-7556. [10.1002/ejoc.201500998]
Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin-Platinum(II) Complex
D'ERRICO, STEFANO;OLIVIERO, GIORGIA;BORBONE, NICOLA;Cerullo, Vincenzo;NICI, FABRIZIA;MAYOL, LUCIANO;PICCIALLI, VINCENZO;PICCIALLI, GENNARO
2015
Abstract
Herein, the synthesis of a nucleoside platinum(II) complex in which a cisplatin-like unit is joined to 7-deazaadenosine through an amino alkyl chain installed at the C6 position of purine was explored. The capability of the new complex to react with DNA purine bases was confirmed by a model reaction with deoxyguanosine monophosphate, whereas its antiproliferative activity against A549 and Cal27 human cancer cell lines was studied by sulforhodamine B assay in comparison with its unplatinated precursor and cisplatin.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
