It is well known that pituitary TSH exerts the major task in the regulation of thyroid function. However, this gland is capable of certain degree of autonomy, independently of TSH control. Iodine plays an important role in thyroid physiology and biochemistry. The thyroid is capable of producing different iodolipids such as 2-iodohexadecanal (2-IHDA). It was shown that this iodolipid mimic some of the inhibitory effects of excess iodide on several thyroid parameters.
2-Iodohexadecanal inhibits thyroid cell growth in part through the induction of let-7f microRNA / Salvarredi, Leonardo A; Thomasz, Lisa; Rossich, Luciano E; Saiselet, Manuel; Pisarev, Mario A; Fusco, Alfredo; Juvenal, Guillermo J.. - In: MOLECULAR AND CELLULAR ENDOCRINOLOGY. - ISSN 0303-7207. - 414:(2015), pp. 224-232. [10.1016/j.mce.2015.07.007]
2-Iodohexadecanal inhibits thyroid cell growth in part through the induction of let-7f microRNA
FUSCO, ALFREDO;
2015
Abstract
It is well known that pituitary TSH exerts the major task in the regulation of thyroid function. However, this gland is capable of certain degree of autonomy, independently of TSH control. Iodine plays an important role in thyroid physiology and biochemistry. The thyroid is capable of producing different iodolipids such as 2-iodohexadecanal (2-IHDA). It was shown that this iodolipid mimic some of the inhibitory effects of excess iodide on several thyroid parameters.| File | Dimensione | Formato | |
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