Objective: To assess the psychometric properties of the Italian adaptation of the Hypomania-Check-List 32-item, second revision (HCL-32-R2) for the detection of bipolarity in major depressive disorder (MDD) treatment-seeking outpatients. Methods: A back-to-back Italian adaption of the “Bipolar Disorders: Improving Diagnosis, Guidance, and Education” English module of the HCL-32-R2 was administered between March 2013 and October 2014 across twelve collaborating sites in Italy. Diagnostic and Statistical Manual Fourth edition (DSM-IV) diagnoses were made adopting the mini-international neuropsychiatric interview, using bipolar disorder (BD) patients as controls. Results: In our sample (n=441, of whom, BD-I=68; BD-II=117; MDD=256), using a cut-off of 14 allowed the HCL-32-R2 to discriminate DSM-IV-defined MDD patients between “true unipolar” (HCL-32-R2−) and “sub-threshold bipolar depression” (HCL-32-R2+) with sensitivity=89% and specificity=79%. Area under the curve was .888; positive and negative predictive values were 75.34% and 90.99% respectively. Owing to clinical interpretability considerations and consistency with previous adaptations of the HCL-32, a two-factor solution (F1=“hyperactive/elated” vs. F2=“irritable/distractible/impulsive”) was preferred using exploratory and confirmatory factor analyses, whereas items n.33 (“I gamble more”) and n.34 (“I eat more”) introduced in the R2 version of the scale slightly loaded onto F2 and F1 respectively. Cronbach׳s α=.88 for F1 and .71 for F2. Limitations: No cross-validation with any additional validated screening tool; treatment-seeking outpatient sample; recall bias; no systematic evaluation of eventual medical/psychiatric comorbidities, current/lifetime pharmacological history, neither record of severity of current MDE. Conclusions: Our results seem to indicate fair accuracy of HCL-32 as a screening instrument for BD, though replication studies are warranted.

Factor structure and reliability of the Italian adaptation of the Hypomania Check List-32, second revision (HCL-32-R2) / Fornaro, Michele; De Berardis, D; Mazza, M; Pino, M; Favaretto, E; Bedani, F; Wieser, C; Indelicato, L; Paternò, Vf; Lo Monaco, F; Dugo, F; Ventriglio, A; Mungo, S; Selle, V; Valchera, A; Elassy, M; Martinotti, G; DE BARTOLOMEIS, Andrea; Iasevoli, Felice; Tomasetti, Carmine; Avvisati, L; Tartaglione, S; Perna, G; Cattaneo, Ci; Consoli, G; Romano, A; Del Debbio, A; Martino, M; Angelo E, D'; De Pasquale, C; Koshy, As; Angst, J.. - In: JOURNAL OF AFFECTIVE DISORDERS. - ISSN 0165-0327. - 178:(2015), pp. 112-120. [10.1016/j.jad.2015.03.001]

Factor structure and reliability of the Italian adaptation of the Hypomania Check List-32, second revision (HCL-32-R2).

FORNARO, MICHELE;DE BARTOLOMEIS, ANDREA;IASEVOLI, FELICE;TOMASETTI, CARMINE;
2015

Abstract

Objective: To assess the psychometric properties of the Italian adaptation of the Hypomania-Check-List 32-item, second revision (HCL-32-R2) for the detection of bipolarity in major depressive disorder (MDD) treatment-seeking outpatients. Methods: A back-to-back Italian adaption of the “Bipolar Disorders: Improving Diagnosis, Guidance, and Education” English module of the HCL-32-R2 was administered between March 2013 and October 2014 across twelve collaborating sites in Italy. Diagnostic and Statistical Manual Fourth edition (DSM-IV) diagnoses were made adopting the mini-international neuropsychiatric interview, using bipolar disorder (BD) patients as controls. Results: In our sample (n=441, of whom, BD-I=68; BD-II=117; MDD=256), using a cut-off of 14 allowed the HCL-32-R2 to discriminate DSM-IV-defined MDD patients between “true unipolar” (HCL-32-R2−) and “sub-threshold bipolar depression” (HCL-32-R2+) with sensitivity=89% and specificity=79%. Area under the curve was .888; positive and negative predictive values were 75.34% and 90.99% respectively. Owing to clinical interpretability considerations and consistency with previous adaptations of the HCL-32, a two-factor solution (F1=“hyperactive/elated” vs. F2=“irritable/distractible/impulsive”) was preferred using exploratory and confirmatory factor analyses, whereas items n.33 (“I gamble more”) and n.34 (“I eat more”) introduced in the R2 version of the scale slightly loaded onto F2 and F1 respectively. Cronbach׳s α=.88 for F1 and .71 for F2. Limitations: No cross-validation with any additional validated screening tool; treatment-seeking outpatient sample; recall bias; no systematic evaluation of eventual medical/psychiatric comorbidities, current/lifetime pharmacological history, neither record of severity of current MDE. Conclusions: Our results seem to indicate fair accuracy of HCL-32 as a screening instrument for BD, though replication studies are warranted.
2015
Factor structure and reliability of the Italian adaptation of the Hypomania Check List-32, second revision (HCL-32-R2) / Fornaro, Michele; De Berardis, D; Mazza, M; Pino, M; Favaretto, E; Bedani, F; Wieser, C; Indelicato, L; Paternò, Vf; Lo Monaco, F; Dugo, F; Ventriglio, A; Mungo, S; Selle, V; Valchera, A; Elassy, M; Martinotti, G; DE BARTOLOMEIS, Andrea; Iasevoli, Felice; Tomasetti, Carmine; Avvisati, L; Tartaglione, S; Perna, G; Cattaneo, Ci; Consoli, G; Romano, A; Del Debbio, A; Martino, M; Angelo E, D'; De Pasquale, C; Koshy, As; Angst, J.. - In: JOURNAL OF AFFECTIVE DISORDERS. - ISSN 0165-0327. - 178:(2015), pp. 112-120. [10.1016/j.jad.2015.03.001]
File in questo prodotto:
File Dimensione Formato  
Full-text FINALE (ITA).pdf

non disponibili

Tipologia: Documento in Post-print
Licenza: Accesso privato/ristretto
Dimensione 788.05 kB
Formato Adobe PDF
788.05 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/610441
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 13
social impact