The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural data unambiguously prove that cisplatin mainly binds to His105 and Met329 side chains; additional binding sites are detected at His288, Met298, and Met548 and at His535, His67 and His247.
Cisplatin binding to human serum albumin: a structural study / Ferraro, G; Massai, L; Messori, L; Merlino, Antonello. - In: CHEMICAL COMMUNICATIONS. - ISSN 1364-548X. - 51:46(2015), pp. 9436-9439. [10.1039/c5cc01751c]
Cisplatin binding to human serum albumin: a structural study
Ferraro G;MERLINO, ANTONELLO
2015
Abstract
The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural data unambiguously prove that cisplatin mainly binds to His105 and Met329 side chains; additional binding sites are detected at His288, Met298, and Met548 and at His535, His67 and His247.File in questo prodotto:
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