Photodermatology represents one of the most important research field in dermatology. During the last twenty years a good deal of progress has been made both in phototherapy and in photodiagnosis, as well as in the development of new irradiative sources. Ultraviolet irradiation, alone or in combination with psoralens, influences the immune system not only in the irradiated areas but also in the unirradiated ones. The UV exposure: 1) diminishes the skin ability to elicit a contact hypersensitivity reaction; 2) reduces the number of Langerhans cells; 3) alters the rejection of transplanted UV-radiation-induced tumors in mice; 4) induces changes in lymphocyte recirculation. Arachidonate transformation products play a mayor role as mediators of most type of delayed UV erythema: after UVB irradiation (18-48 hr) skin levels of prostaglandin E2, F2α, D2, 6 ketoPGF1α and 12 HETE are increased. Khellin, a molecule with a low phototoxic activity, is now currently used for vitiligo treatment, nevertheless other photosensitizing agents, not binding the DNA, could have some potential in photochemiotherapy of psoriasis. Several lasers are successfully employed in dermatology for the treatment of portwine stains (argon, dye and copper lasers) or tatoos (Nd-Yag and Q-switched ruby lasers). Laser technology will provide multipurpose, cheaper, smaller and user-friendly lasers such as tunable solid-state and semiconductor lasers that will certainly be useful in dermatology.

Photodermatology today

SANTOIANNI, PIETRO;MONFRECOLA, GIUSEPPE
1993

Abstract

Photodermatology represents one of the most important research field in dermatology. During the last twenty years a good deal of progress has been made both in phototherapy and in photodiagnosis, as well as in the development of new irradiative sources. Ultraviolet irradiation, alone or in combination with psoralens, influences the immune system not only in the irradiated areas but also in the unirradiated ones. The UV exposure: 1) diminishes the skin ability to elicit a contact hypersensitivity reaction; 2) reduces the number of Langerhans cells; 3) alters the rejection of transplanted UV-radiation-induced tumors in mice; 4) induces changes in lymphocyte recirculation. Arachidonate transformation products play a mayor role as mediators of most type of delayed UV erythema: after UVB irradiation (18-48 hr) skin levels of prostaglandin E2, F2α, D2, 6 ketoPGF1α and 12 HETE are increased. Khellin, a molecule with a low phototoxic activity, is now currently used for vitiligo treatment, nevertheless other photosensitizing agents, not binding the DNA, could have some potential in photochemiotherapy of psoriasis. Several lasers are successfully employed in dermatology for the treatment of portwine stains (argon, dye and copper lasers) or tatoos (Nd-Yag and Q-switched ruby lasers). Laser technology will provide multipurpose, cheaper, smaller and user-friendly lasers such as tunable solid-state and semiconductor lasers that will certainly be useful in dermatology.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/607240
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