Using a new phototest procedure, experimental lesions have been elicited in twelve patients with clinical diagnosis of polymorphous light eruption (PLE), papular type. A skin area (5 x 10 cm), in which the patient had had genuine eruption of PLE, has been daily irradiated with polychromatic UVB (80% of MED) + UVA (25 J/sq cm) + VIS (170 J/sq cm). All patients showed a papular eruption after 3-7 irradiative sessions. No response was observed on the control area receiving only polychromatic UVA (60J/sq cm) in repeated sessions (up to ten), according to Holzle's method. Our results suggest that the interaction among different wavelengths could play an important role in the pathogenesis of PLE.

Polymorphous light eruption: Experimental reproduction of isomorphic skin lesions by a new method

MONFRECOLA, GIUSEPPE;
1992

Abstract

Using a new phototest procedure, experimental lesions have been elicited in twelve patients with clinical diagnosis of polymorphous light eruption (PLE), papular type. A skin area (5 x 10 cm), in which the patient had had genuine eruption of PLE, has been daily irradiated with polychromatic UVB (80% of MED) + UVA (25 J/sq cm) + VIS (170 J/sq cm). All patients showed a papular eruption after 3-7 irradiative sessions. No response was observed on the control area receiving only polychromatic UVA (60J/sq cm) in repeated sessions (up to ten), according to Holzle's method. Our results suggest that the interaction among different wavelengths could play an important role in the pathogenesis of PLE.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/607237
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