The aim of the present work is to investigate the feasibility and effects of a selective post-deposition laser treatment on titanium coatings. Commercially pure titanium grade 2 powders were deposited by means of a cold spray process on aluminum alloy AA2024-T3 sheets. The surface treatment of the coating was realized using a 220 W diode laser. The influence of heat input and dimensional features of coating layer and substrate was assessed by an experimental campaign conducted following a design of experiments approach. Optical and scanning electron microscopy analysis of the microstructure of the deposited and treated material as well as micro hardness measurements showed the formation of a compact layer of titanium oxide on the coating surface and the preservation of the temper state of the aluminum substrate.