A chemoproteomic-driven approach was used to investigate the interaction network between human telomeric G-quadruplex DNA and nuclear proteins. We identified novel G-quadruplex binding partners, able to recognize these DNA structures at chromosome ends, suggesting a possible, and so far unknown, role of these proteins in telomere functions.

Identification of novel interactors of human telomeric G-quadruplex DNA

PAGANO, BRUNO
Primo
;
AMATO, JUSSARA;IACCARINO, NUNZIA;NOVELLINO, ETTORE;RANDAZZO, ANTONIO
Ultimo
2015

Abstract

A chemoproteomic-driven approach was used to investigate the interaction network between human telomeric G-quadruplex DNA and nuclear proteins. We identified novel G-quadruplex binding partners, able to recognize these DNA structures at chromosome ends, suggesting a possible, and so far unknown, role of these proteins in telomere functions.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/602369
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