A chemoproteomic-driven approach was used to investigate the interaction network between human telomeric G-quadruplex DNA and nuclear proteins. We identified novel G-quadruplex binding partners, able to recognize these DNA structures at chromosome ends, suggesting a possible, and so far unknown, role of these proteins in telomere functions.
Identification of novel interactors of human telomeric G-quadruplex DNA / Pagano, Bruno; L., Margarucci; P., Zizza; Amato, Jussara; Iaccarino, Nunzia; C., Cassiano; E., Salvati; Novellino, Ettore; A., Biroccio; A., Casapullo; Randazzo, Antonio. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 51:14(2015), pp. 2964-2967. [10.1039/c4cc07231f]
Identification of novel interactors of human telomeric G-quadruplex DNA
PAGANO, BRUNO
Primo
;AMATO, JUSSARA;IACCARINO, NUNZIA;NOVELLINO, ETTORE;RANDAZZO, ANTONIOUltimo
2015
Abstract
A chemoproteomic-driven approach was used to investigate the interaction network between human telomeric G-quadruplex DNA and nuclear proteins. We identified novel G-quadruplex binding partners, able to recognize these DNA structures at chromosome ends, suggesting a possible, and so far unknown, role of these proteins in telomere functions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
