Nitroxyl (HNO), the I-electron reduced and protonated congener of nitric oxide (NO), has received recent attention as a potential pharmacological agent for the treatment of heart failure and as a preconditioning agent for the mitigation of ischemia-reperfusion injury. Interest in the pharmacology and biology of HNO has prompted examination, or in some instances reexamination, of many of its chemical properties. Such studies have provided insight into the chemical basis for the biological effects of HNO, although the biochemical mechanisms for many of these effects remain to be established. In this review, a brief description of the biologically relevant chemistry of HNO is given, followed by a more detailed discussion of the pharmacology and potential toxicology of HNO. (c) 2006 Elsevier Inc. All rights reserved.

The pharmacology of nitroxyl (HNO) and its therapeutic potential: Not just the janus face of NO / Paolocci, Nazareno; Jackson Matthew, I.; Lopez Brenda, E.; Miranda, Katrina; Tocchetti, CARLO GABRIELE; Wink David, A.; Hobbs, A. d. r. i. a. n. J.; Fukuto Jon, M.. - In: PHARMACOLOGY & THERAPEUTICS. - ISSN 0163-7258. - 113:2(2007), pp. 442-458. [10.1016/j.pharmthera.2006.11.002]

The pharmacology of nitroxyl (HNO) and its therapeutic potential: Not just the janus face of NO

TOCCHETTI, CARLO GABRIELE;
2007

Abstract

Nitroxyl (HNO), the I-electron reduced and protonated congener of nitric oxide (NO), has received recent attention as a potential pharmacological agent for the treatment of heart failure and as a preconditioning agent for the mitigation of ischemia-reperfusion injury. Interest in the pharmacology and biology of HNO has prompted examination, or in some instances reexamination, of many of its chemical properties. Such studies have provided insight into the chemical basis for the biological effects of HNO, although the biochemical mechanisms for many of these effects remain to be established. In this review, a brief description of the biologically relevant chemistry of HNO is given, followed by a more detailed discussion of the pharmacology and potential toxicology of HNO. (c) 2006 Elsevier Inc. All rights reserved.
2007
The pharmacology of nitroxyl (HNO) and its therapeutic potential: Not just the janus face of NO / Paolocci, Nazareno; Jackson Matthew, I.; Lopez Brenda, E.; Miranda, Katrina; Tocchetti, CARLO GABRIELE; Wink David, A.; Hobbs, A. d. r. i. a. n. J.; Fukuto Jon, M.. - In: PHARMACOLOGY & THERAPEUTICS. - ISSN 0163-7258. - 113:2(2007), pp. 442-458. [10.1016/j.pharmthera.2006.11.002]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/599400
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