Several technologies developed by the Italian institute of nuclear physics (INFN) for fundamental physics have been applied to medical imaging and particle therapy techniques. The partnership with leading industries has always been crucial for successful applications. Within this framework is the implementation of a Treatment Planning System (TPS) for hadrontherapy with C-ion beams, but not exclusively, in partnership with the IBA Group, with the contribution of the TPS manufacturer Elekta. Several INFN research groups that have developed competencies in different scientific areas are cooperating to the task: experimental and phenomenological nuclear physics, Monte Carlo (MC) and techniques for numerical analysis, radiobiology and hardware development for monitoring purposes. A TPS prototype is currently being studied. In order to achieve a fast plan optimization, the dose distribution is computed using look-up tables obtained from MC simulations. These are performed using Fluka and an implementation of the Local Effect Model (developed by the GSI Biophysics group). Nuclear fragmentation experiments for C-ion are now performed at the INFN???s Laboratori Nazionali del Sud (LNS) (30-80 MeV/n). Further experiments are scheduled at SIS (GSI) in the framework of the FIRST experiment (200-400 MeV/n), in collaboration with other European Institutes (GSI, ESA, CEA). Radiobiological experiments are underway at LNS and Laboratori Nazionali di Legnaro, on rodent and human cells (C-ion @ 8-80 MeV/n). Lighter ions (A = 6-12) will also be used, to reproduce the effects of fragments (up to 20 MeV/u). These experiments will provide reliable data for the validation of the simulations and for further improvements of the physical and radiobiological models to be used in the TPS.

The INFN Treatment Planning System Project

GROSSI, GIANFRANCO
2010

Abstract

Several technologies developed by the Italian institute of nuclear physics (INFN) for fundamental physics have been applied to medical imaging and particle therapy techniques. The partnership with leading industries has always been crucial for successful applications. Within this framework is the implementation of a Treatment Planning System (TPS) for hadrontherapy with C-ion beams, but not exclusively, in partnership with the IBA Group, with the contribution of the TPS manufacturer Elekta. Several INFN research groups that have developed competencies in different scientific areas are cooperating to the task: experimental and phenomenological nuclear physics, Monte Carlo (MC) and techniques for numerical analysis, radiobiology and hardware development for monitoring purposes. A TPS prototype is currently being studied. In order to achieve a fast plan optimization, the dose distribution is computed using look-up tables obtained from MC simulations. These are performed using Fluka and an implementation of the Local Effect Model (developed by the GSI Biophysics group). Nuclear fragmentation experiments for C-ion are now performed at the INFN???s Laboratori Nazionali del Sud (LNS) (30-80 MeV/n). Further experiments are scheduled at SIS (GSI) in the framework of the FIRST experiment (200-400 MeV/n), in collaboration with other European Institutes (GSI, ESA, CEA). Radiobiological experiments are underway at LNS and Laboratori Nazionali di Legnaro, on rodent and human cells (C-ion @ 8-80 MeV/n). Lighter ions (A = 6-12) will also be used, to reproduce the effects of fragments (up to 20 MeV/u). These experiments will provide reliable data for the validation of the simulations and for further improvements of the physical and radiobiological models to be used in the TPS.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/598605
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