Background: Age-related effects on the ability of 6-min walking test (6MWT) and ejection fraction (EF) to predict mortality in coronary artery bypass grafting (CABG) patients undergoing cardiac rehabilitation (CR) is still debated. Design and methods: In order to verify the role of 6MWT and EF on all-cause mortality in patients undergoing CR following CABG, 882 CABG patients undergoing CR stratified in adults (<65 years) and elderly (65 years) were studied. Results: At the admission, EF was 52.69.1% in adults and 51.38.9% in elderly (p¼0.234, NS) while 6MWT was 343.893.5 m in adults and 258.995.7 m in elderly (p<0.001). After 42.914.1 months follow up, mortality was 8.2% in adults and 10.9% in elderly (p¼0.176, NS). Cox regression analysis shows that EF50% and 6MWT 300 m are protective on mortality in all CABG patients before CR. However, EF 50% in adults (HR 0.18, 95% CI 0.06–0.49, p<0.005) but not in elderly (HR 1.16, 95% CI 0.45–3.42, p¼0.354, NS) and 6MWT 300 m in elderly (HR 0.34, 95% CI 0.10–0.79, p¼0.033) but not in adults (HR 0.76, 95% CI 0.31–2.12, p¼0.654, NS) exert a protective role on mortality. Conclusions: Our results indicate that both EF50% and 6MWT300 m independently protect against mortality in CABG patients before CR. However, their protective role is age dependent. In fact, EF50% is protective in adults but not in elderly while 6MWT300 m is protective in elderly but not in adult patients.

Six-minute walking test but not ejection fraction predicts mortality in elderly patients undergoingcardiac rehabilitation following coronary artery bypass grafting.

Cacciatore F;ABETE, PASQUALE
;
FERRARA, NICOLA;
2012

Abstract

Background: Age-related effects on the ability of 6-min walking test (6MWT) and ejection fraction (EF) to predict mortality in coronary artery bypass grafting (CABG) patients undergoing cardiac rehabilitation (CR) is still debated. Design and methods: In order to verify the role of 6MWT and EF on all-cause mortality in patients undergoing CR following CABG, 882 CABG patients undergoing CR stratified in adults (<65 years) and elderly (65 years) were studied. Results: At the admission, EF was 52.69.1% in adults and 51.38.9% in elderly (p¼0.234, NS) while 6MWT was 343.893.5 m in adults and 258.995.7 m in elderly (p<0.001). After 42.914.1 months follow up, mortality was 8.2% in adults and 10.9% in elderly (p¼0.176, NS). Cox regression analysis shows that EF50% and 6MWT 300 m are protective on mortality in all CABG patients before CR. However, EF 50% in adults (HR 0.18, 95% CI 0.06–0.49, p<0.005) but not in elderly (HR 1.16, 95% CI 0.45–3.42, p¼0.354, NS) and 6MWT 300 m in elderly (HR 0.34, 95% CI 0.10–0.79, p¼0.033) but not in adults (HR 0.76, 95% CI 0.31–2.12, p¼0.654, NS) exert a protective role on mortality. Conclusions: Our results indicate that both EF50% and 6MWT300 m independently protect against mortality in CABG patients before CR. However, their protective role is age dependent. In fact, EF50% is protective in adults but not in elderly while 6MWT300 m is protective in elderly but not in adult patients.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/598407
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