Adenosine A2A receptor has been described to be antinflammatory in several models of acute and chronic inflammation. Furthermore, the same receptor is also involved in adenosine-mediated wound healing in vivo; in vitro, in primary human dermal fibroblasts, there is evidence that A2A receptor mediates the collagen-inducing effect of adenosine. Fibroblast growth factor-2 (FGF-2) is a growth factor playing a role in tissue proliferation, wound healing and also in inflammation. High levels of FGF-2 have been found in bronchoalveolar lavage fluids (BALFs) from asthmatic subjects; moreover, in a murine model of asthma, recombinant FGF-2 has been shown to reduce airway responsiveness; furthermore, FGF-2 has also been shown to reduce acute inflammation. In the present study we have investigated on the possible involvement of FGF-2 in the antinflammatory effect of the A2A agonist, CGS21680.

A2A receptor agonist, CGS21680, inhibits inflammation and increases FGF-2 tissue expression in carrageenan induced rat paw edema

CAIAZZO, ELISABETTA;IALENTI, ARMANDO;CICALA, CARLA
2014

Abstract

Adenosine A2A receptor has been described to be antinflammatory in several models of acute and chronic inflammation. Furthermore, the same receptor is also involved in adenosine-mediated wound healing in vivo; in vitro, in primary human dermal fibroblasts, there is evidence that A2A receptor mediates the collagen-inducing effect of adenosine. Fibroblast growth factor-2 (FGF-2) is a growth factor playing a role in tissue proliferation, wound healing and also in inflammation. High levels of FGF-2 have been found in bronchoalveolar lavage fluids (BALFs) from asthmatic subjects; moreover, in a murine model of asthma, recombinant FGF-2 has been shown to reduce airway responsiveness; furthermore, FGF-2 has also been shown to reduce acute inflammation. In the present study we have investigated on the possible involvement of FGF-2 in the antinflammatory effect of the A2A agonist, CGS21680.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/597415
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