The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A and B, hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism.
Isolation and Assessment of the In Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea / Esposito, Germana; Teta, Roberta; Roberta, Miceli; Luca, Ceccarelli; DELLA SALA, Gerardo; Rosa, Camerlingo; Elena, Irollo; Mangoni, Alfonso; Giuseppe, Pirozzi; Costantino, Valeria. - In: MARINE DRUGS. - ISSN 1660-3397. - 13:1(2015), pp. 444-459. [10.3390/md13010444]
Isolation and Assessment of the In Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea
ESPOSITO, GERMANA;TETA, ROBERTACo-primo
;DELLA SALA, GERARDO;MANGONI, ALFONSO;COSTANTINO, VALERIA
Ultimo
2015
Abstract
The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A and B, hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
