We have studied the antibacterial, antifungal and antitumor activity of Mytilus galloprovincialis’ protamine-like. Nine bacterial strains were employed. They included two Gram-positive and seven Gram-negative bacteria. The same clinically isolated (CI) bacterial strains were used to compare the sensitivity to these proteins. Antifungal tests were done on 3 strains of fungi including: 1 potentially pathogenic yeast (Candida albicans CI) and 2 filamentous phytopathogenic fungi Botrytis cinerea and Rhyzoctonia solani. Mytilus galloprovincialis’ protamine-like inhibited all bacteria strains with different MBC values ranging from 7.8 to 250 µg/mL and resulted active also on some tested bacteria strains that are generally resistant to conventional antibiotics. They showed also a fungistatic effect on all the fungi tested, with MFCs ranging from 16 to 32 µg/mL and cytotoxic effects on RKO colon cancer cells starting from a concentration of protamine-like 15 µg/mL.
Antibacterial, antifungal and antitumor activity of Mytilus galloprovincialis’ protamine-like / Basile, Adriana; Turano, Mimmo; A., Murolo; F., Caccavale; F., Pollice; G., Speranza; S., Avagnano; D., Drongitis; Notomista, Eugenio; Fucci, Laura; J., Ausió; Piscopo, Marina. - 570:22(2014), pp. 61-61. (Intervento presentato al convegno XIII FISV CONGRESS tenutosi a pisa nel 24-27 settembre 2014).
Antibacterial, antifungal and antitumor activity of Mytilus galloprovincialis’ protamine-like
BASILE, ADRIANA;TURANO, MIMMO;NOTOMISTA, EUGENIO;FUCCI, LAURA;PISCOPO, MARINA
2014
Abstract
We have studied the antibacterial, antifungal and antitumor activity of Mytilus galloprovincialis’ protamine-like. Nine bacterial strains were employed. They included two Gram-positive and seven Gram-negative bacteria. The same clinically isolated (CI) bacterial strains were used to compare the sensitivity to these proteins. Antifungal tests were done on 3 strains of fungi including: 1 potentially pathogenic yeast (Candida albicans CI) and 2 filamentous phytopathogenic fungi Botrytis cinerea and Rhyzoctonia solani. Mytilus galloprovincialis’ protamine-like inhibited all bacteria strains with different MBC values ranging from 7.8 to 250 µg/mL and resulted active also on some tested bacteria strains that are generally resistant to conventional antibiotics. They showed also a fungistatic effect on all the fungi tested, with MFCs ranging from 16 to 32 µg/mL and cytotoxic effects on RKO colon cancer cells starting from a concentration of protamine-like 15 µg/mL.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.