We have studied the antibacterial, antifungal and antitumor activity of Mytilus galloprovincialis’ protamine-like. Nine bacterial strains were employed. They included two Gram-positive and seven Gram-negative bacteria. The same clinically isolated (CI) bacterial strains were used to compare the sensitivity to these proteins. Antifungal tests were done on 3 strains of fungi including: 1 potentially pathogenic yeast (Candida albicans CI) and 2 filamentous phytopathogenic fungi Botrytis cinerea and Rhyzoctonia solani. Mytilus galloprovincialis’ protamine-like inhibited all bacteria strains with different MBC values ranging from 7.8 to 250 µg/mL and resulted active also on some tested bacteria strains that are generally resistant to conventional antibiotics. They showed also a fungistatic effect on all the fungi tested, with MFCs ranging from 16 to 32 µg/mL and cytotoxic effects on RKO colon cancer cells starting from a concentration of protamine-like 15 µg/mL.

Antibacterial, antifungal and antitumor activity of Mytilus galloprovincialis’ protamine-like

BASILE, ADRIANA;TURANO, MIMMO;NOTOMISTA, EUGENIO;FUCCI, LAURA;PISCOPO, MARINA
2014

Abstract

We have studied the antibacterial, antifungal and antitumor activity of Mytilus galloprovincialis’ protamine-like. Nine bacterial strains were employed. They included two Gram-positive and seven Gram-negative bacteria. The same clinically isolated (CI) bacterial strains were used to compare the sensitivity to these proteins. Antifungal tests were done on 3 strains of fungi including: 1 potentially pathogenic yeast (Candida albicans CI) and 2 filamentous phytopathogenic fungi Botrytis cinerea and Rhyzoctonia solani. Mytilus galloprovincialis’ protamine-like inhibited all bacteria strains with different MBC values ranging from 7.8 to 250 µg/mL and resulted active also on some tested bacteria strains that are generally resistant to conventional antibiotics. They showed also a fungistatic effect on all the fungi tested, with MFCs ranging from 16 to 32 µg/mL and cytotoxic effects on RKO colon cancer cells starting from a concentration of protamine-like 15 µg/mL.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/593747
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