The use of porous silica nanoparticles (PSN) offers new perspectives in drug delivery and cancer therapy. PSN exhibit considerable potential for biological applications because of their biocompatibility, biodegradability and tunable porous nanostructure for drug delivery. Another advantage is the possibility to modify their external as well as internal surfaces. Nano-surface modification has proven to be beneficial for improving nanocarrier drug delivery and provides a wide range of functionalities. The aim of this study was to define the biocompatibility of the PSN and to settle a suitable experimental protocol to functionalize PSN.
Porous silicon nanoparticles for cellular delivery of anticancer molecules / Martucci, NICOLA MASSIMILIANO; Ruggiero, Immacolata; Migliaccio, Nunzia; I., Rea; Arcari, Paolo; Lamberti, Annalisa. - In: THE FEBS JOURNAL. - ISSN 1742-4658. - 280:(2013), pp. 310-310. [10.1111/febs.12340]
Porous silicon nanoparticles for cellular delivery of anticancer molecules
MARTUCCI, NICOLA MASSIMILIANO;RUGGIERO, IMMACOLATA;MIGLIACCIO, NUNZIA;ARCARI, PAOLO;LAMBERTI, ANNALISA
2013
Abstract
The use of porous silica nanoparticles (PSN) offers new perspectives in drug delivery and cancer therapy. PSN exhibit considerable potential for biological applications because of their biocompatibility, biodegradability and tunable porous nanostructure for drug delivery. Another advantage is the possibility to modify their external as well as internal surfaces. Nano-surface modification has proven to be beneficial for improving nanocarrier drug delivery and provides a wide range of functionalities. The aim of this study was to define the biocompatibility of the PSN and to settle a suitable experimental protocol to functionalize PSN.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
