LPMV is the etiologic agent of “blue eye disease”, a disease endemic in Mexico, which mainly affects piglets and is characterized by meningoencephalitis and respiratory distress. The V protein, expressed by most Paramyxoviruses, evade the type I and type II IFN responses by targeting the signaling pathway. In this study we set out to determine if LPMV-V protein possesses IFN signaling antagonist activity, and to identify which signaling components if any are targeted by LPMV-V protein. We demonstrate that LPMV-V protein antagonizes type I but not type II IFN signaling by inhibiting STAT2. Our results indicate that the last 25 amino acids of LPMV-V protein bind endogenous STAT2

LA PROTEINA V DEL VIRUS LPMV (LA PIEDAD MICHOACAN MESSICO VIRUS) ANTAGONIZZA LA RISPOSTA DI TIPO I DELL’INTERFERONE LEGANDOSI ALLA PROTEINA STAT2 E PREVENENDONE LA TRASLOCAZIONE / Pisanelli, Giuseppe; Manicassamy, B.; Laurent rolle, M.; Belicha villanueva, A.; Morrison, J.; Iovane, Giuseppe; Garcia Sastre, A.. - volume degli atti:1(2012), pp. 101-102. (Intervento presentato al convegno XIV Congresso Nazionale S.I.Di.L.V. tenutosi a Sorrento Napoli nel 24-26 Ottobre 2012).

LA PROTEINA V DEL VIRUS LPMV (LA PIEDAD MICHOACAN MESSICO VIRUS) ANTAGONIZZA LA RISPOSTA DI TIPO I DELL’INTERFERONE LEGANDOSI ALLA PROTEINA STAT2 E PREVENENDONE LA TRASLOCAZIONE.

PISANELLI, GIUSEPPE;IOVANE, GIUSEPPE;
2012

Abstract

LPMV is the etiologic agent of “blue eye disease”, a disease endemic in Mexico, which mainly affects piglets and is characterized by meningoencephalitis and respiratory distress. The V protein, expressed by most Paramyxoviruses, evade the type I and type II IFN responses by targeting the signaling pathway. In this study we set out to determine if LPMV-V protein possesses IFN signaling antagonist activity, and to identify which signaling components if any are targeted by LPMV-V protein. We demonstrate that LPMV-V protein antagonizes type I but not type II IFN signaling by inhibiting STAT2. Our results indicate that the last 25 amino acids of LPMV-V protein bind endogenous STAT2
2012
LA PROTEINA V DEL VIRUS LPMV (LA PIEDAD MICHOACAN MESSICO VIRUS) ANTAGONIZZA LA RISPOSTA DI TIPO I DELL’INTERFERONE LEGANDOSI ALLA PROTEINA STAT2 E PREVENENDONE LA TRASLOCAZIONE / Pisanelli, Giuseppe; Manicassamy, B.; Laurent rolle, M.; Belicha villanueva, A.; Morrison, J.; Iovane, Giuseppe; Garcia Sastre, A.. - volume degli atti:1(2012), pp. 101-102. (Intervento presentato al convegno XIV Congresso Nazionale S.I.Di.L.V. tenutosi a Sorrento Napoli nel 24-26 Ottobre 2012).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/593521
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