Background: Currently no tools to predict risk of acute (AP) and recurrent pancreatitis (ARP) in children with cystic fibrosis (CF) are available. We assessed the prevalence of AP/ARP and tested the potential role of Pancreatic Insufficiency Prevalence (PIP) score in a cohort of children with CF. Methods: We identified two groups of children, on the basis of presence/absence of AP/ARP, who were compared for age at diagnosis, clinical features, genotypes and sweat chloride level. PIP score was calculated for each patient. Results: 10/167 (5.9%) experienced at least one episode of AP during follow up; 10/10 were pancreatic sufficient (PS). Patients with AP/ARP showed a PIP score ≤ 0.25 more frequently (6/10) than patients without AP/ARP. The odds ratio (95% CI) of developing pancreatitis was 4.54 (1.22-16.92) for patients with PIP < 0.25 when compared with those who have a PIP score > 0.25 (p 0.0151). PIP score was correlated with sweat chloride test (p < 0.01). Conclusion: PIP score, PS status and normal/borderline sweat chloride levels could be applied to predict pancreatitis development in children with CF. ARP could lead to pancreatic insufficiency. © 2014 European Cystic Fibrosis Society

Prediction of acute pancreatitis risk based on PIP score in children with cystic fibrosis / Terlizzi, Vito; A., Tosco; Tomaiuolo, Rossella; A., Sepe; N., Amato; A., Casale; C., Mercogliano; F., De Gregorio; F., Improta; A., Elce; Castaldo, Giuseppe; Raia, Valeria. - In: JOURNAL OF CYSTIC FIBROSIS. - ISSN 1569-1993. - 13:(2014), pp. 579-584. [10.1016/j.jcf.2014.01.007]

Prediction of acute pancreatitis risk based on PIP score in children with cystic fibrosis

TERLIZZI, VITO;TOMAIUOLO, ROSSELLA;CASTALDO, GIUSEPPE;RAIA, VALERIA
2014

Abstract

Background: Currently no tools to predict risk of acute (AP) and recurrent pancreatitis (ARP) in children with cystic fibrosis (CF) are available. We assessed the prevalence of AP/ARP and tested the potential role of Pancreatic Insufficiency Prevalence (PIP) score in a cohort of children with CF. Methods: We identified two groups of children, on the basis of presence/absence of AP/ARP, who were compared for age at diagnosis, clinical features, genotypes and sweat chloride level. PIP score was calculated for each patient. Results: 10/167 (5.9%) experienced at least one episode of AP during follow up; 10/10 were pancreatic sufficient (PS). Patients with AP/ARP showed a PIP score ≤ 0.25 more frequently (6/10) than patients without AP/ARP. The odds ratio (95% CI) of developing pancreatitis was 4.54 (1.22-16.92) for patients with PIP < 0.25 when compared with those who have a PIP score > 0.25 (p 0.0151). PIP score was correlated with sweat chloride test (p < 0.01). Conclusion: PIP score, PS status and normal/borderline sweat chloride levels could be applied to predict pancreatitis development in children with CF. ARP could lead to pancreatic insufficiency. © 2014 European Cystic Fibrosis Society
2014
Prediction of acute pancreatitis risk based on PIP score in children with cystic fibrosis / Terlizzi, Vito; A., Tosco; Tomaiuolo, Rossella; A., Sepe; N., Amato; A., Casale; C., Mercogliano; F., De Gregorio; F., Improta; A., Elce; Castaldo, Giuseppe; Raia, Valeria. - In: JOURNAL OF CYSTIC FIBROSIS. - ISSN 1569-1993. - 13:(2014), pp. 579-584. [10.1016/j.jcf.2014.01.007]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/592275
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