Two novel opioid analogues have been designed by substituting the native d-Ala residues in position 2,2' of biphalin with two residues of d-penicillamine or l-penicillamine and by forming a disulfide bond between the thiol groups. The so-obtained compound 9 containing d-penicillamines showed excellent μ/δ mixed receptor affinities (K i (δ) = 5.2 nM; K i (μ) = 1.9 nM), together with an efficacious capacity to trigger the second messenger and a very good in vivo antinociceptive activity, whereas product 10 was scarcely active. An explanation of the two different pharmacological behaviors of products 9 and 10 was found by studying their conformational properties.

Novel cyclic biphalin analogue with improved antinociceptive properties / Mollica, A; Carotenuto, Alfonso; Novellino, Ettore; Limatola, Antonio; Costante, R; Pinnen, F; Stefanucci, A; Pieretti, S; Borsodi, A; Samavati, R; Zador, F; Benyhe, S; Davis, P; Porreca, F; Hruby, V. J.. - In: ACS MEDICINAL CHEMISTRY LETTERS. - ISSN 1948-5875. - 5:9(2014), pp. 1032-1036. [10.1021/ml500241n]

Novel cyclic biphalin analogue with improved antinociceptive properties.

CAROTENUTO, ALFONSO
;
NOVELLINO, ETTORE;LIMATOLA, ANTONIO;
2014

Abstract

Two novel opioid analogues have been designed by substituting the native d-Ala residues in position 2,2' of biphalin with two residues of d-penicillamine or l-penicillamine and by forming a disulfide bond between the thiol groups. The so-obtained compound 9 containing d-penicillamines showed excellent μ/δ mixed receptor affinities (K i (δ) = 5.2 nM; K i (μ) = 1.9 nM), together with an efficacious capacity to trigger the second messenger and a very good in vivo antinociceptive activity, whereas product 10 was scarcely active. An explanation of the two different pharmacological behaviors of products 9 and 10 was found by studying their conformational properties.
2014
Novel cyclic biphalin analogue with improved antinociceptive properties / Mollica, A; Carotenuto, Alfonso; Novellino, Ettore; Limatola, Antonio; Costante, R; Pinnen, F; Stefanucci, A; Pieretti, S; Borsodi, A; Samavati, R; Zador, F; Benyhe, S; Davis, P; Porreca, F; Hruby, V. J.. - In: ACS MEDICINAL CHEMISTRY LETTERS. - ISSN 1948-5875. - 5:9(2014), pp. 1032-1036. [10.1021/ml500241n]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/586581
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