In this study we assessed the BDNF promoter IV methylation state of a large genomic region surrounding promoter IV and evaluated BDNF transcript IV expression from prefrontal cortex and striatum of 15 schizophrenic and 15 control subjects. In prefrontal cortex, a single CpG site at -93, appeared to be undermethylated in patients׳group. BDNF mRNA levels in frontal cortex and striatum were variable among individuals but did not associate with disease.
DNA methylation state of BDNF gene is not altered in prefrontal cortex and striatum of schizophrenia subjects / Keller, Simona; Errico, Francesco; Zarrilli, F; Florio, Ermanno; Punzo, Daniela; Mansueto, S; Angrisano, Tiziana; Pero, Raffaela; Lembo, Francesca; Castaldo, Giuseppe; Usiello, A; Chiariotti, Lorenzo. - In: PSYCHIATRY RESEARCH. - ISSN 0165-1781. - 220:3(2014), pp. 1147-1150. [10.1016/j.psychres.2014.08.022]
DNA methylation state of BDNF gene is not altered in prefrontal cortex and striatum of schizophrenia subjects.
KELLER, SIMONA;ERRICO, FRANCESCO;Zarrilli F;FLORIO, ERMANNO;PUNZO, DANIELA;ANGRISANO, TIZIANA;PERO, RAFFAELA;LEMBO, FRANCESCA;CASTALDO, GIUSEPPE;CHIARIOTTI, LORENZO
2014
Abstract
In this study we assessed the BDNF promoter IV methylation state of a large genomic region surrounding promoter IV and evaluated BDNF transcript IV expression from prefrontal cortex and striatum of 15 schizophrenic and 15 control subjects. In prefrontal cortex, a single CpG site at -93, appeared to be undermethylated in patients׳group. BDNF mRNA levels in frontal cortex and striatum were variable among individuals but did not associate with disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
