In this study we assessed the BDNF promoter IV methylation state of a large genomic region surrounding promoter IV and evaluated BDNF transcript IV expression from prefrontal cortex and striatum of 15 schizophrenic and 15 control subjects. In prefrontal cortex, a single CpG site at -93, appeared to be undermethylated in patients׳group. BDNF mRNA levels in frontal cortex and striatum were variable among individuals but did not associate with disease.

DNA methylation state of BDNF gene is not altered in prefrontal cortex and striatum of schizophrenia subjects / Keller, Simona; Errico, Francesco; Zarrilli, F; Florio, Ermanno; Punzo, Daniela; Mansueto, S; Angrisano, Tiziana; Pero, Raffaela; Lembo, Francesca; Castaldo, Giuseppe; Usiello, A; Chiariotti, Lorenzo. - In: PSYCHIATRY RESEARCH. - ISSN 0165-1781. - 220:3(2014), pp. 1147-1150. [10.1016/j.psychres.2014.08.022]

DNA methylation state of BDNF gene is not altered in prefrontal cortex and striatum of schizophrenia subjects.

KELLER, SIMONA;ERRICO, FRANCESCO;Zarrilli F;FLORIO, ERMANNO;PUNZO, DANIELA;ANGRISANO, TIZIANA;PERO, RAFFAELA;LEMBO, FRANCESCA;CASTALDO, GIUSEPPE;CHIARIOTTI, LORENZO
2014

Abstract

In this study we assessed the BDNF promoter IV methylation state of a large genomic region surrounding promoter IV and evaluated BDNF transcript IV expression from prefrontal cortex and striatum of 15 schizophrenic and 15 control subjects. In prefrontal cortex, a single CpG site at -93, appeared to be undermethylated in patients׳group. BDNF mRNA levels in frontal cortex and striatum were variable among individuals but did not associate with disease.
2014
DNA methylation state of BDNF gene is not altered in prefrontal cortex and striatum of schizophrenia subjects / Keller, Simona; Errico, Francesco; Zarrilli, F; Florio, Ermanno; Punzo, Daniela; Mansueto, S; Angrisano, Tiziana; Pero, Raffaela; Lembo, Francesca; Castaldo, Giuseppe; Usiello, A; Chiariotti, Lorenzo. - In: PSYCHIATRY RESEARCH. - ISSN 0165-1781. - 220:3(2014), pp. 1147-1150. [10.1016/j.psychres.2014.08.022]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/586355
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