Water buffalo (Bubalus bubalis) are susceptible to bovine herpesvirus type 1 (BoHV-1) and a species-specific herpesvirus, bubaline herpesvirus type 1 (BuHV-1). In this study, an attenuated marker BoHV-1 based vaccine against BuHV-1 challenge was evaluated to determine whether it induces protection from viral replication. One group of water buffalo calves was immunized with an attenuated BoHV-1 marker vaccine. A second group was not vaccinated and used as the control. During the post-vaccination period, we monitored the humoral immune response. The efficacy of the vaccine was tested after intranasal challenge of the calves with a BuHV-1 strain. The experiment showed that after vaccination, BuHV-1 replication was significantly reduced by approximately three titer points compared to the controls. The control animals showed high levels of viral shedding and mild signs associated with BuHV-1 infection. Therefore, our study provides evidence for the existence of cross-protection between BoHV-1 and BuHV-1 in buffalo calves.

Bovine herpesvirus type 1 marker vaccine induces cross-protection against bubaline herpesvirus type 1 in water buffalo / Montagnaro, Serena; De Martinis, C; Iovane, Valentina; Ciarcia, Roberto; Damiano, Sara; Nizza, Sandra; DE MARTINO, Luisa; Iovane, Giuseppe; Pagnini, Ugo. - In: PREVENTIVE VETERINARY MEDICINE. - ISSN 0167-5877. - sept 1:116(2014), pp. 56-62. [10.1016/j.prevetmed.2014.06.002.]

Bovine herpesvirus type 1 marker vaccine induces cross-protection against bubaline herpesvirus type 1 in water buffalo

MONTAGNARO, SERENA;IOVANE, VALENTINA;CIARCIA, ROBERTO;Damiano, Sara;NIZZA, SANDRA;DE MARTINO, LUISA;IOVANE, GIUSEPPE;PAGNINI, UGO
2014

Abstract

Water buffalo (Bubalus bubalis) are susceptible to bovine herpesvirus type 1 (BoHV-1) and a species-specific herpesvirus, bubaline herpesvirus type 1 (BuHV-1). In this study, an attenuated marker BoHV-1 based vaccine against BuHV-1 challenge was evaluated to determine whether it induces protection from viral replication. One group of water buffalo calves was immunized with an attenuated BoHV-1 marker vaccine. A second group was not vaccinated and used as the control. During the post-vaccination period, we monitored the humoral immune response. The efficacy of the vaccine was tested after intranasal challenge of the calves with a BuHV-1 strain. The experiment showed that after vaccination, BuHV-1 replication was significantly reduced by approximately three titer points compared to the controls. The control animals showed high levels of viral shedding and mild signs associated with BuHV-1 infection. Therefore, our study provides evidence for the existence of cross-protection between BoHV-1 and BuHV-1 in buffalo calves.
2014
Bovine herpesvirus type 1 marker vaccine induces cross-protection against bubaline herpesvirus type 1 in water buffalo / Montagnaro, Serena; De Martinis, C; Iovane, Valentina; Ciarcia, Roberto; Damiano, Sara; Nizza, Sandra; DE MARTINO, Luisa; Iovane, Giuseppe; Pagnini, Ugo. - In: PREVENTIVE VETERINARY MEDICINE. - ISSN 0167-5877. - sept 1:116(2014), pp. 56-62. [10.1016/j.prevetmed.2014.06.002.]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/585377
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