Foldamers provide an attractive medium to test the mechanisms by which biological macromolecules fold into complex three-dimensional structures, and ultimately to design novel protein-like architectures with properties unprecedented in nature. Here, we describe a large cage-like structure formed from an amphiphilic arylamide foldamer crystallized from aqueous solution. Forty-eight copies of the foldamer assemble into a 5-nm cage-like structure, an omnitruncated octahedron filled with well-ordered ice-like water molecules. The assembly is stabilized by a mix of arylamide stacking interaction, hydrogen bonding and hydrophobic forces. The omnitruncated octahedra tessellate to form a cubic crystal. These findings may provide an important step towards the design of nanostructured particles resembling spherical viruses.
Crystal structure of an amphiphilic foldamer reveals a 48-mer assembly comprising a hollow truncated octahedron / Pavone, Vincenzo; Shao Qing, Zhang; Merlino, Antonello; Lombardi, Angelina; Yibing, Wu; William F., Degrado. - In: NATURE COMMUNICATIONS. - ISSN 2041-1723. - 5:(2014), p. 3581. [10.1038/ncomms4581]
Crystal structure of an amphiphilic foldamer reveals a 48-mer assembly comprising a hollow truncated octahedron
PAVONE, VINCENZO;MERLINO, ANTONELLO;LOMBARDI, ANGELINA;
2014
Abstract
Foldamers provide an attractive medium to test the mechanisms by which biological macromolecules fold into complex three-dimensional structures, and ultimately to design novel protein-like architectures with properties unprecedented in nature. Here, we describe a large cage-like structure formed from an amphiphilic arylamide foldamer crystallized from aqueous solution. Forty-eight copies of the foldamer assemble into a 5-nm cage-like structure, an omnitruncated octahedron filled with well-ordered ice-like water molecules. The assembly is stabilized by a mix of arylamide stacking interaction, hydrogen bonding and hydrophobic forces. The omnitruncated octahedra tessellate to form a cubic crystal. These findings may provide an important step towards the design of nanostructured particles resembling spherical viruses.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.