Objective: n-3 Polyunsaturated fatty acids (PUFAs) supplementation reduces systemic inflammation and improves renal and cardiovascular prognosis in kidney transplant recipients. However, patient compliance is poor because bad-tasting fish oils are used as an n-3 PUFA source. Therefore, we explored whether the beneficial effects of n-3 can be obtained by administering a diet based on n-3-rich foods. Methods: Sixty kidney transplant recipients were assigned to 2 different groups: the CON group (n = 28), which continued with their usual diet, and the DIET group (n = 32), which followed an n-3-rich diet for 6 months. Twenty-six patients in the DIET group and 24 in the CON group completed the study. End points of the study were changes in n-3 PUFAs intake, n-6:n-3 PUFAs ratio, systemic inflammation markers, and renal function during the 6 months of the dietary treatment. Results: Three and 6 months after the beginning of the study, n-3 PUFA intake was significantly higher and the n-6:n-3 PUFA ratio was markedly lower than baseline in the DIET group. Plasma total cholesterol, triglycerides, C-reactive protein, and interleukin (IL)-6 decreased as well. IL-6 mRNA levels in peripheral blood mononuclear cells were also lower than at the beginning of the study. Proteinuria and microalbuminuria were reduced by 50% with respect to the baseline, whereas glomerular filtration rate (GFR) was unchanged. No change in the aforementioned parameters was observed in the CON group throughout the study. Conclusion: In long-term kidney transplant recipients a naturally n-3 PUFA-rich dietary plan causes an increase in n-3 PUFA intake, decreases systemic inflammation and proteinuria, and improves plasma lipid pattern.

Effects of a diet rich in N-3 polyunsaturated Fatty acids on systemic inflammation in renal transplant recipients / Sabbatini, Massimo; Apicella, L; Cataldi, Mauro; Maresca, I; Nastasi, Annamaria; Vitale, S; Memoli, Bruno; Postiglione, Loredana; Riccio, E; Gallo, R; Federico, Stefano; Guida, Bruna. - In: JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION. - ISSN 0731-5724. - 32:6(2013), pp. 375-383. [10.1080/07315724.2013.826482]

Effects of a diet rich in N-3 polyunsaturated Fatty acids on systemic inflammation in renal transplant recipients.

SABBATINI, MASSIMO;CATALDI, MAURO;NASTASI, ANNAMARIA;MEMOLI, BRUNO;POSTIGLIONE, LOREDANA;FEDERICO, STEFANO;GUIDA, BRUNA
2013

Abstract

Objective: n-3 Polyunsaturated fatty acids (PUFAs) supplementation reduces systemic inflammation and improves renal and cardiovascular prognosis in kidney transplant recipients. However, patient compliance is poor because bad-tasting fish oils are used as an n-3 PUFA source. Therefore, we explored whether the beneficial effects of n-3 can be obtained by administering a diet based on n-3-rich foods. Methods: Sixty kidney transplant recipients were assigned to 2 different groups: the CON group (n = 28), which continued with their usual diet, and the DIET group (n = 32), which followed an n-3-rich diet for 6 months. Twenty-six patients in the DIET group and 24 in the CON group completed the study. End points of the study were changes in n-3 PUFAs intake, n-6:n-3 PUFAs ratio, systemic inflammation markers, and renal function during the 6 months of the dietary treatment. Results: Three and 6 months after the beginning of the study, n-3 PUFA intake was significantly higher and the n-6:n-3 PUFA ratio was markedly lower than baseline in the DIET group. Plasma total cholesterol, triglycerides, C-reactive protein, and interleukin (IL)-6 decreased as well. IL-6 mRNA levels in peripheral blood mononuclear cells were also lower than at the beginning of the study. Proteinuria and microalbuminuria were reduced by 50% with respect to the baseline, whereas glomerular filtration rate (GFR) was unchanged. No change in the aforementioned parameters was observed in the CON group throughout the study. Conclusion: In long-term kidney transplant recipients a naturally n-3 PUFA-rich dietary plan causes an increase in n-3 PUFA intake, decreases systemic inflammation and proteinuria, and improves plasma lipid pattern.
2013
Effects of a diet rich in N-3 polyunsaturated Fatty acids on systemic inflammation in renal transplant recipients / Sabbatini, Massimo; Apicella, L; Cataldi, Mauro; Maresca, I; Nastasi, Annamaria; Vitale, S; Memoli, Bruno; Postiglione, Loredana; Riccio, E; Gallo, R; Federico, Stefano; Guida, Bruna. - In: JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION. - ISSN 0731-5724. - 32:6(2013), pp. 375-383. [10.1080/07315724.2013.826482]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/575243
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