L-DOPA-induced dyskinesia, the rate-limiting side effect in the therapy of Parkinson's disease, is mediated by activation of mammalian target of rapamycin (mTOR) signaling in the striatum. We found that Ras homolog enriched in striatum (Rhes), a striatal-specific protein, binds to and activates mTOR. Moreover, Rhes(-/-) mice showed reduced striatal mTOR signaling and diminished dyskinesia, but maintained motor improvement on L-DOPA treatment, suggesting a therapeutic benefit for Rhes-binding drugs.

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA?induced dyskinesia / Srinivasa, Subramaniam; Napolitano, Francesco; Robert G., Mealer; Seyun, Kim; Errico, Francesco; Roxanne, Barrow; Neelam, Shahani; Richa, Tyagi; Solomon H., Snyder; Alessandro, Usiello. - In: NATURE NEUROSCIENCE. - ISSN 1097-6256. - 15:(2011), pp. 191-193. [10.1038/nn.2994]

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA?induced dyskinesia

NAPOLITANO, Francesco;ERRICO, FRANCESCO;
2011

Abstract

L-DOPA-induced dyskinesia, the rate-limiting side effect in the therapy of Parkinson's disease, is mediated by activation of mammalian target of rapamycin (mTOR) signaling in the striatum. We found that Ras homolog enriched in striatum (Rhes), a striatal-specific protein, binds to and activates mTOR. Moreover, Rhes(-/-) mice showed reduced striatal mTOR signaling and diminished dyskinesia, but maintained motor improvement on L-DOPA treatment, suggesting a therapeutic benefit for Rhes-binding drugs.
2011
Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA?induced dyskinesia / Srinivasa, Subramaniam; Napolitano, Francesco; Robert G., Mealer; Seyun, Kim; Errico, Francesco; Roxanne, Barrow; Neelam, Shahani; Richa, Tyagi; Solomon H., Snyder; Alessandro, Usiello. - In: NATURE NEUROSCIENCE. - ISSN 1097-6256. - 15:(2011), pp. 191-193. [10.1038/nn.2994]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/574451
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