The use of charged particles significantly reduces the dose absorbed by normal cells due to the inverse dose-depth deposition profile. This is the physical pillar justifying hadrontherapy as the eligible treatment for deepseated tumours. However, a non-negligible amount of radiation is nevertheless absorbed in correspondence with the plateau region of the Bragg curve, which may result in the induction of sub-lethal effects. Very little experimental data exist on the induction of such effects. Moreover, reliable follow-up data on such adverse effects in hadrontherapy patients are limited since this type of treatment has been adopted relatively recently. A fortiori, the dependence of sub-lethal effects on unprecedented factors, such as the exceedingly high dose rates and/or the pulsed nature of beams originated by laser interaction with target materials, is unknown. This warrants investigation prior to a therapeutic use of such beams.

Chromosome aberrations and cellular premature senescence as radiation-induced sub-lethal effects: Implications for laser-driven charged-particle radiotherapy / Manti, Lorenzo; Perozziello, Francesca Margaret; Grossi, Gianfranco. - 1546:(2013), pp. 90-92. (Intervento presentato al convegno 2nd ELIMED Workshop tenutosi a Catania nel 18-19 ottobre 2012) [10.1063/1.4816613].

Chromosome aberrations and cellular premature senescence as radiation-induced sub-lethal effects: Implications for laser-driven charged-particle radiotherapy

MANTI, LORENZO;Perozziello, Francesca Margaret;GROSSI, GIANFRANCO
2013

Abstract

The use of charged particles significantly reduces the dose absorbed by normal cells due to the inverse dose-depth deposition profile. This is the physical pillar justifying hadrontherapy as the eligible treatment for deepseated tumours. However, a non-negligible amount of radiation is nevertheless absorbed in correspondence with the plateau region of the Bragg curve, which may result in the induction of sub-lethal effects. Very little experimental data exist on the induction of such effects. Moreover, reliable follow-up data on such adverse effects in hadrontherapy patients are limited since this type of treatment has been adopted relatively recently. A fortiori, the dependence of sub-lethal effects on unprecedented factors, such as the exceedingly high dose rates and/or the pulsed nature of beams originated by laser interaction with target materials, is unknown. This warrants investigation prior to a therapeutic use of such beams.
2013
9780735411715
Chromosome aberrations and cellular premature senescence as radiation-induced sub-lethal effects: Implications for laser-driven charged-particle radiotherapy / Manti, Lorenzo; Perozziello, Francesca Margaret; Grossi, Gianfranco. - 1546:(2013), pp. 90-92. (Intervento presentato al convegno 2nd ELIMED Workshop tenutosi a Catania nel 18-19 ottobre 2012) [10.1063/1.4816613].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/573550
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