We evaluated the protective effect of Diltiazem from pacing-induced myocardial ischemia in 9 patients (pts) with coronary heart disease (CAD) and stable effort angina by studying the changes in systemic and coronary hemodynamics during pacing. Hemodynamic parameters were evaluated at baseline and at peak pacing before and after Diltiazem, 25 mg i.v. Diltiazem prevented angina in 6 of 7 pts who presented angina in the control pacing. This beneficial effect was accompanied at peak pacing rate by a significant fall in ST depression, arterial pressure, rate-pressure product and left ventricular (LV) end-diastolic pressure, while no significant changes were observed in LV dp/dt max, coronary blood flow and coronary vascular resistance. Therefore, Diltiazem exerts a protective effect from pacing-induced myocardial ischemia in pts with CAD and stable effort angina, without impairing LV function. This beneficial effect is due to a reduction in myocardial metabolic requirements, rather than to an improvement of blood supply to the ischemic myocardium.
Beneficial effects of diltiazem in patients with stable angina on effort. Evaluation by pacing-induced changes in coronary and systemic hemodynamics [EFFETTI FAVOREVOLI DEL DILTIAZEM NELL'ANGINA STABILE DA SFORZO. VALUTAZIONE DELL'EMODINAMICA CORONARICA DURANTE PACING] / Vigorito, C.; Giordano, A.; de Caprio, L.; Vitale, D.; Ferrara, Nicola; Canonico, V.; Silvestri, P.; Casaburi, E.; Ferraro, P.; Rengo, F.. - In: GIORNALE ITALIANO DI CARDIOLOGIA. - ISSN 0046-5968. - 16:(1986), pp. 1032-1036.
Beneficial effects of diltiazem in patients with stable angina on effort. Evaluation by pacing-induced changes in coronary and systemic hemodynamics [EFFETTI FAVOREVOLI DEL DILTIAZEM NELL'ANGINA STABILE DA SFORZO. VALUTAZIONE DELL'EMODINAMICA CORONARICA DURANTE PACING]
FERRARA, NICOLA;
1986
Abstract
We evaluated the protective effect of Diltiazem from pacing-induced myocardial ischemia in 9 patients (pts) with coronary heart disease (CAD) and stable effort angina by studying the changes in systemic and coronary hemodynamics during pacing. Hemodynamic parameters were evaluated at baseline and at peak pacing before and after Diltiazem, 25 mg i.v. Diltiazem prevented angina in 6 of 7 pts who presented angina in the control pacing. This beneficial effect was accompanied at peak pacing rate by a significant fall in ST depression, arterial pressure, rate-pressure product and left ventricular (LV) end-diastolic pressure, while no significant changes were observed in LV dp/dt max, coronary blood flow and coronary vascular resistance. Therefore, Diltiazem exerts a protective effect from pacing-induced myocardial ischemia in pts with CAD and stable effort angina, without impairing LV function. This beneficial effect is due to a reduction in myocardial metabolic requirements, rather than to an improvement of blood supply to the ischemic myocardium.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
