Many questions are unanswered on the optimal management of chronically HBV-infected children. Chronic hepatitis B is generally a mild disease in children; response to therapy is partial and limited to specific subgroups; available drugs have no proven advantage on long-term course versus no treatment, and are hampered by numerous limits. Studies on natural history of chronic hepatitis B and the long-term results of the therapeutic schedules adopted so far should be critically appraised. A balance between the potential benefits of the treatment and its side effects, and the spontaneous course of the disease left untreated should be made.
What evidence to support antiviral treatment in children with chronic hepatitis B? / Iorio, Raffaele; Maria, Tufano; Giagnorio, Maria G.; Spagnuolo, Maria I.; Antonietta, Giannattasio. - In: ANTIVIRAL THERAPY. - ISSN 1359-6535. - (2013). [10.3851/IMP2704]
What evidence to support antiviral treatment in children with chronic hepatitis B?
IORIO, RAFFAELE;Maria I. Spagnuolo;
2013
Abstract
Many questions are unanswered on the optimal management of chronically HBV-infected children. Chronic hepatitis B is generally a mild disease in children; response to therapy is partial and limited to specific subgroups; available drugs have no proven advantage on long-term course versus no treatment, and are hampered by numerous limits. Studies on natural history of chronic hepatitis B and the long-term results of the therapeutic schedules adopted so far should be critically appraised. A balance between the potential benefits of the treatment and its side effects, and the spontaneous course of the disease left untreated should be made.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
