Trans-activation response DNA-binding protein of 43 kDa (TDP-43), a key factor in several neurodegenerative conditions, was discovered as a novel target of heteronemin by chemical proteomics. Combining bio-physical orthogonal approaches with biological analysis, heteronemin was found to influence the binding of TDP-43-cognate nucleic acids and to modulate the TDP-43 aggregation state and its cellular localization

Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders / C., Cassiano; R., Esposito; A., Tosco; Zampella, Angela; D'Auria, MARIA VALERIA; R., Riccio; A., Casapullo; M. C., Monti. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 50:4(2014), pp. 406-408. [10.1039/c3cc45454a]

Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders

ZAMPELLA, ANGELA;D'AURIA, MARIA VALERIA;M. C. Monti
2014

Abstract

Trans-activation response DNA-binding protein of 43 kDa (TDP-43), a key factor in several neurodegenerative conditions, was discovered as a novel target of heteronemin by chemical proteomics. Combining bio-physical orthogonal approaches with biological analysis, heteronemin was found to influence the binding of TDP-43-cognate nucleic acids and to modulate the TDP-43 aggregation state and its cellular localization
2014
Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders / C., Cassiano; R., Esposito; A., Tosco; Zampella, Angela; D'Auria, MARIA VALERIA; R., Riccio; A., Casapullo; M. C., Monti. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 50:4(2014), pp. 406-408. [10.1039/c3cc45454a]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/570221
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