The prepn. of gadolinium complexes of peptide conjugates as contrast agents for use in NMR (MRI) is described. This novel class of contrast agents may be used to identify and locate primary human tumors and their metastases which over-express type CCK A and/or type B cholecystokinin receptors, and/or type SSTR 1-5 somatostatin receptors (no data). Thus, gadolinium DTPA-peptide deriv. conjugates with Gly-CCK8 or vapreotide were prepd. (DTPA = diethylenetriaminepentaacetic acid, Gly-CCK8 = H-Gly-Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2).

PEPTIDES CONJUGATES, THEIR DERIVATIVES WITH METAL COMPLEXES AND USE THEREOF FOR MAGNETIC RESONANCE IMAGING (MRI).

MORELLI, GIANCARLO;PEDONE, CARLO;TESAURO, DIEGO;
2003

Abstract

The prepn. of gadolinium complexes of peptide conjugates as contrast agents for use in NMR (MRI) is described. This novel class of contrast agents may be used to identify and locate primary human tumors and their metastases which over-express type CCK A and/or type B cholecystokinin receptors, and/or type SSTR 1-5 somatostatin receptors (no data). Thus, gadolinium DTPA-peptide deriv. conjugates with Gly-CCK8 or vapreotide were prepd. (DTPA = diethylenetriaminepentaacetic acid, Gly-CCK8 = H-Gly-Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2).
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/5702
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