Partially N-acetylated chitooligosaccharides and muropeptides are referred to as microbial associated molecular patterns (MAMPs). To shed light on the molecular basis of their recognition by the innate immunity system of living organisms, their production in pure form is necessary. To this end, we present here the first synthetic strategy for the obtainment of a series of partially N-acetylated muropeptides as well as of a chitodisaccharide and a chitotetrasaccharide, all possessing a well-defined N-acetylation pattern.

Synthesis of partially N-acetylated chitooligosaccharides and muropeptides / Bedini, Emiliano; L., Cirillo; Marchetti, Roberta; Basso, Sara; Tufano, Diego; Molinaro, Antonio; Parrilli, Michelangelo. - In: SYNLETT. - ISSN 0936-5214. - 25:(2014), pp. 365-370. [10.1055/s-0033-1340323]

Synthesis of partially N-acetylated chitooligosaccharides and muropeptides

BEDINI, EMILIANO;MARCHETTI, ROBERTA;BASSO, SARA;TUFANO, DIEGO;MOLINARO, ANTONIO;PARRILLI, MICHELANGELO
2014

Abstract

Partially N-acetylated chitooligosaccharides and muropeptides are referred to as microbial associated molecular patterns (MAMPs). To shed light on the molecular basis of their recognition by the innate immunity system of living organisms, their production in pure form is necessary. To this end, we present here the first synthetic strategy for the obtainment of a series of partially N-acetylated muropeptides as well as of a chitodisaccharide and a chitotetrasaccharide, all possessing a well-defined N-acetylation pattern.
2014
Synthesis of partially N-acetylated chitooligosaccharides and muropeptides / Bedini, Emiliano; L., Cirillo; Marchetti, Roberta; Basso, Sara; Tufano, Diego; Molinaro, Antonio; Parrilli, Michelangelo. - In: SYNLETT. - ISSN 0936-5214. - 25:(2014), pp. 365-370. [10.1055/s-0033-1340323]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/570088
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