The reaction of Auoxo6, a dinuclear gold(III) complex, with the model protein bovine pancreatic ribonuclease is explored here by X-ray diffraction and ESI mass spectrometry. Data provide clues on the processes of adduct formation and of enzyme inhibition and, inductively, on the likely mode of action of this metallodrug.

Interactions of Gold-based drugs with proteins: crystal structure of the adduct formed between Ribonuclease A and a cytotoxic gold(III) compound / L., Messori; F., Scaletti; L., Massai; M. A., Cinellu; RUSSO KRAUSS, Irene; G., di Martino; Vergara, Alessandro; Paduano, Luigi; Merlino, Antonello. - In: METALLOMICS. - ISSN 1756-5901. - 6:2(2014), pp. 233-236. [10.1039/C3MT00265A]

Interactions of Gold-based drugs with proteins: crystal structure of the adduct formed between Ribonuclease A and a cytotoxic gold(III) compound

RUSSO KRAUSS, IRENE;VERGARA, ALESSANDRO;PADUANO, LUIGI;MERLINO, ANTONELLO
2014

Abstract

The reaction of Auoxo6, a dinuclear gold(III) complex, with the model protein bovine pancreatic ribonuclease is explored here by X-ray diffraction and ESI mass spectrometry. Data provide clues on the processes of adduct formation and of enzyme inhibition and, inductively, on the likely mode of action of this metallodrug.
2014
Interactions of Gold-based drugs with proteins: crystal structure of the adduct formed between Ribonuclease A and a cytotoxic gold(III) compound / L., Messori; F., Scaletti; L., Massai; M. A., Cinellu; RUSSO KRAUSS, Irene; G., di Martino; Vergara, Alessandro; Paduano, Luigi; Merlino, Antonello. - In: METALLOMICS. - ISSN 1756-5901. - 6:2(2014), pp. 233-236. [10.1039/C3MT00265A]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/568778
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