Recently, microRNAs (miRNAs) were identified able to inhibit the expression of the Cystic Fibrosis Transmembrane Regulator (CFTR) disease-gene of Cystic Fibrosis (CF) and CFTR-Related Disorders (CFTR-RD). This study shows the use of peptide nucleic acids (PNAs) as inhibitors of miR-509-3p, one of the CFTR regulating miRNAs, by reverting the expression of luciferase gene containing the 3 'UTR of CFTR gene.

Design, synthesis and biochemical investigation, by in vitro luciferase reporter system, of peptide nucleic acids as new inhibitors of miR-509-3p involved in the regulation of cystic fibrosis disease-gene expression

AMATO, FELICE;TOMAIUOLO, ROSSELLA;BORBONE, NICOLA;AMATO, JUSSARA;D'ERRICO, STEFANO;DE ROSA, GIUSEPPE;MAYOL, LAURA;PICCIALLI, GENNARO;OLIVIERO, GIORGIA;CASTALDO, GIUSEPPE
2014

Abstract

Recently, microRNAs (miRNAs) were identified able to inhibit the expression of the Cystic Fibrosis Transmembrane Regulator (CFTR) disease-gene of Cystic Fibrosis (CF) and CFTR-Related Disorders (CFTR-RD). This study shows the use of peptide nucleic acids (PNAs) as inhibitors of miR-509-3p, one of the CFTR regulating miRNAs, by reverting the expression of luciferase gene containing the 3 'UTR of CFTR gene.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/565805
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