In this work we explore the ability of a chimeric LNA/DNA bent duplex, in which the kink is induced by 2 unpaired adenines in the middle of one strand, to bind HMGB1, a protein involved in many inflammatory processes. The LNA/DNA duplex was compared with the corresponding full DNA and PNA/DNA chimera duplexes from a thermodynamic and spectroscopic point of view.

Bent Oligonucleotide Duplexes as HMGB1 Inhibitors: a Comparative Study / Musumeci, Domenica; G. N., Roviello; M., Moccia; Pedone, Carlo; E. M., Bucci; R., Sapio; M., Valente; S., Fumero. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - STAMPA. - 26:(2007), pp. 1447-1450. [10.1080/15257770701542330]

Bent Oligonucleotide Duplexes as HMGB1 Inhibitors: a Comparative Study

MUSUMECI, DOMENICA;PEDONE, CARLO;
2007

Abstract

In this work we explore the ability of a chimeric LNA/DNA bent duplex, in which the kink is induced by 2 unpaired adenines in the middle of one strand, to bind HMGB1, a protein involved in many inflammatory processes. The LNA/DNA duplex was compared with the corresponding full DNA and PNA/DNA chimera duplexes from a thermodynamic and spectroscopic point of view.
2007
Bent Oligonucleotide Duplexes as HMGB1 Inhibitors: a Comparative Study / Musumeci, Domenica; G. N., Roviello; M., Moccia; Pedone, Carlo; E. M., Bucci; R., Sapio; M., Valente; S., Fumero. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - STAMPA. - 26:(2007), pp. 1447-1450. [10.1080/15257770701542330]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/565519
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