Chemically modified siRNAs were synthesized to enhance the corresponding silencing activities. The introduced modifications endowed siRNAs with high silencing effect, long RNAi persistence, and better serum resistance. Theoretical data allowed us to correlate the observed siRNAs interfering performance with the peculiar interactions with PAZ.
Tuning RNA Interference by Enhancing siRNA/PAZ Recognition / Maria, Gaglione; Nicoletta, Potenza; DI FABIO, Giovanni; Romanucci, Valeria; Nicola, Mosca; Aniello, Russo; Novellino, Ettore; Sandro, Cosconati; Anna, Messere. - In: ACS MEDICINAL CHEMISTRY LETTERS. - ISSN 1948-5875. - 4:(2012), pp. 75-78. [10.1021/ml300284b]
Tuning RNA Interference by Enhancing siRNA/PAZ Recognition
DI FABIO, GIOVANNI;ROMANUCCI, VALERIA;NOVELLINO, ETTORE;
2012
Abstract
Chemically modified siRNAs were synthesized to enhance the corresponding silencing activities. The introduced modifications endowed siRNAs with high silencing effect, long RNAi persistence, and better serum resistance. Theoretical data allowed us to correlate the observed siRNAs interfering performance with the peculiar interactions with PAZ.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
