Lipoxygenase (LOX) inhibitors are well known for their anti-inflammatory effects derived from both natural products and synthetic sources. Taxus wallichiana Zucc is traditionally used in the treatment of various diseases including inflammation. In a recent study, it was used to conduce the isolation of the bioactive compounds from Taxus wallichiana Zucc. thanks to its ethnopharmacological use in diseases including inflammation. Phytochemical studies lead to the isolation of abietane diterpenoids, namely Taxusabietane C (TC) and Taxamairin F (TF). Test compounds showed significant LOX inhibitory effects. IC50 values of TC and TF were 69 +/- A 0.31 and 73 +/- A 0.14 mu M, respectively. The standard compound Baicalein and Tenidap sodium showed the IC50 value being 22.1 +/- A 0.03 and 41.6 +/- A 0.02 mu M. Significant LOX inhibitory activities were supported by a molecular docking simulation to explore molecular interactions of the compounds with the active (catalytic) site of LOX.
Molecular insights to explore abietane diterpenes as new LOX inhibitors / Inamullah, Khan; Muhammad, Nisar; Zarrelli, Armando; DI FABIO, Giovanni; Farah, Gul; Syed Naeemuddin, Gilani; Muhammad Raza, Shah; Amir Zada, Khan; Samiullah, ; Hazrat, Amin. - In: MEDICINAL CHEMISTRY RESEARCH. - ISSN 1054-2523. - 22:12(2013), pp. 5809-5813. [10.1007/s00044-013-0559-7]
Molecular insights to explore abietane diterpenes as new LOX inhibitors
ZARRELLI, ARMANDO;DI FABIO, GIOVANNI;
2013
Abstract
Lipoxygenase (LOX) inhibitors are well known for their anti-inflammatory effects derived from both natural products and synthetic sources. Taxus wallichiana Zucc is traditionally used in the treatment of various diseases including inflammation. In a recent study, it was used to conduce the isolation of the bioactive compounds from Taxus wallichiana Zucc. thanks to its ethnopharmacological use in diseases including inflammation. Phytochemical studies lead to the isolation of abietane diterpenoids, namely Taxusabietane C (TC) and Taxamairin F (TF). Test compounds showed significant LOX inhibitory effects. IC50 values of TC and TF were 69 +/- A 0.31 and 73 +/- A 0.14 mu M, respectively. The standard compound Baicalein and Tenidap sodium showed the IC50 value being 22.1 +/- A 0.03 and 41.6 +/- A 0.02 mu M. Significant LOX inhibitory activities were supported by a molecular docking simulation to explore molecular interactions of the compounds with the active (catalytic) site of LOX.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
