Investigations of heterochiral oligodeoxynucleotides 50-TD1GD2GD3- 30-30-GL3GL2TL1-50 (L33) and 30-TD1GD2GD3-50-50-GL3GL2TL1-30 (L55) forming quadruplex structures are reported. Data indicate the presence of enantiomeric left- and right-handed quadruplex helices. In the case of L55, NMR experiments point to an unusual equilibrium between them.
Titolo: | A novel equilibrium relating to the helix handedness in G-quadruplexes formed by heterochiral oligonucleotides with an inversion of polarity site | |
Autori: | ||
Data di pubblicazione: | 2013 | |
Rivista: | ||
Abstract: | Investigations of heterochiral oligodeoxynucleotides 50-TD1GD2GD3- 30-30-GL3GL2TL1-50 (L33) and ...30-TD1GD2GD3-50-50-GL3GL2TL1-30 (L55) forming quadruplex structures are reported. Data indicate the presence of enantiomeric left- and right-handed quadruplex helices. In the case of L55, NMR experiments point to an unusual equilibrium between them. | |
Handle: | http://hdl.handle.net/11588/563251 | |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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