The first general synthesis of bis-α-acyloxy-1,4- and -1,5-di ketones has been accomplished in a catalytic oxidative open ing of bis-acylated THF and THP (tetrahydropyran) diols, which were synthesised by osmium- or ruthenium-catalysed oxidative cyclisation of 1,5- and 1,6-dienes. The overall sequence corresponds to the regioselective double ketoacylox-ylation of the starting diene. The synthesised bis-α-acyloxy-1,5-dicarbonyl compounds have been transformed into pyridine-based oxido pincer ligands or pyrazinedimethanol substances, leading to the discovery of unprecedented aromatisation routes.
File in questo prodotto:
Non ci sono file associati a questo prodotto.