Myelodysplastic syndromes (MDS) are clonal disorders characterized by ineffective hematopoiesis and possible evolution to acute leukemia. Occurrence of stem cell defects and of immune-mediated mechanisms was evidenced as relevant for pathophysiology of MDS. Here, we described one case of MDS patient carrying CD14+CD56+ monocytes in bone marrow (BM), in the presence of a defective human leukocyte antigen (HLA)-E expression on peripheral blood (PB) cells and of natural killer (NK) cell expansion in PB and BM. The defective HLA-E expression and the NK expansion are proposed to be relevant for the pathogenesis of myelodysplasia in those patients showing CD14+CD56+ monocytes in BM.
NK expansion, HLA-E expression and CD14+CD56+ monocytes in a Myelodysplastic Syndrome Patient / Terrazzano, G., Rubino, V., Palatucci, A.t., Giovazzino, A., Annunziatella, M., Vitagliano, O., Alfinito, F., Ruggiero, G.. - In: EUROPEAN JOURNAL OF HAEMATOLOGY. - ISSN 1600-0609. - 91:(2013), pp. 265-269. [10.1111/ejh.12152]
NK expansion, HLA-E expression and CD14+CD56+ monocytes in a Myelodysplastic Syndrome Patient.
RUBINO, VALENTINA;ALFINITO, FIORELLA;RUGGIERO, GIUSEPPINA
2013
Abstract
Myelodysplastic syndromes (MDS) are clonal disorders characterized by ineffective hematopoiesis and possible evolution to acute leukemia. Occurrence of stem cell defects and of immune-mediated mechanisms was evidenced as relevant for pathophysiology of MDS. Here, we described one case of MDS patient carrying CD14+CD56+ monocytes in bone marrow (BM), in the presence of a defective human leukocyte antigen (HLA)-E expression on peripheral blood (PB) cells and of natural killer (NK) cell expansion in PB and BM. The defective HLA-E expression and the NK expansion are proposed to be relevant for the pathogenesis of myelodysplasia in those patients showing CD14+CD56+ monocytes in BM.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
