We report the synthesis and bio-pharmacological evaluation of a class of pyrrole derivatives featuring a small appendage fragment (carbaldehyde, oxime, nitrile) on the central core. Compound 1c proved to be extremely effective in vivo, showing an interesting anti-nociceptic profile that is comparable to reference compounds already marketed, hence representing a great stimulus for a further improvement of this class of molecules. © 2013 Elsevier Ltd. All rights reserved.

A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity / Battilocchio, C; Poce, G; Alfonso, S; Porretta, Gc; Consalvi, S; Sautebin, Lidia; Pace, Simona; Rossi, Antonietta; Ghelardini, C; Di Cesare Mannelli, L; Schenone, S; Giordani, A; Di Francesco, L; Patrignani, P; Biava, M.. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 21:13(2013), pp. 3695-3701. [10.1016/j.bmc.2013.04.031]

A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity

SAUTEBIN, LIDIA;PACE, SIMONA;ROSSI, ANTONIETTA;
2013

Abstract

We report the synthesis and bio-pharmacological evaluation of a class of pyrrole derivatives featuring a small appendage fragment (carbaldehyde, oxime, nitrile) on the central core. Compound 1c proved to be extremely effective in vivo, showing an interesting anti-nociceptic profile that is comparable to reference compounds already marketed, hence representing a great stimulus for a further improvement of this class of molecules. © 2013 Elsevier Ltd. All rights reserved.
2013
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity / Battilocchio, C; Poce, G; Alfonso, S; Porretta, Gc; Consalvi, S; Sautebin, Lidia; Pace, Simona; Rossi, Antonietta; Ghelardini, C; Di Cesare Mannelli, L; Schenone, S; Giordani, A; Di Francesco, L; Patrignani, P; Biava, M.. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 21:13(2013), pp. 3695-3701. [10.1016/j.bmc.2013.04.031]
File in questo prodotto:
File Dimensione Formato  
Battilocchio 2013 Bioorg Med Chem.pdf

accesso aperto

Tipologia: Documento in Post-print
Licenza: Accesso privato/ristretto
Dimensione 583.31 kB
Formato Adobe PDF
583.31 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/558331
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 86
  • ???jsp.display-item.citation.isi??? 81
social impact