The induction of senescence in tumor cells impairs transformation and promotes an anticancer immune response resulting from the production by senescent cells of cytokines and chemokines, an aspect known as “senescence-associated secretory phenotype” (SASP). Here we discuss recent findings regarding the role of NFκB in the modulation of the SASP and the consequent anticancer immune response.
Senescence and NFκB: A trojan horse in tumors? / Crescenzi, E.; De Palma, R.; Leonardi, Antonio. - In: ONCOIMMUNOLOGY. - ISSN 2162-4011. - 1:9(2012), pp. 1594-1597. [10.4161/onci.22525]
Senescence and NFκB: A trojan horse in tumors?
LEONARDI, ANTONIO
2012
Abstract
The induction of senescence in tumor cells impairs transformation and promotes an anticancer immune response resulting from the production by senescent cells of cytokines and chemokines, an aspect known as “senescence-associated secretory phenotype” (SASP). Here we discuss recent findings regarding the role of NFκB in the modulation of the SASP and the consequent anticancer immune response.File in questo prodotto:
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