The aim of this study was to engineer a scaffold for tissue engineering with double shape pore architecture, with tubular and isotropic pores. A novel method is herein proposed, based on the combination of gas foaming and fiber templating. In particular, the tubular pores have been obtained by leaching of melt–spun saccharide fibers (cottoncandy) within CO2-foamed poly(e-caprolactone). The optimization of the scaffold has been conducted via the selection of the proper saccharide, its thermal treatment to stabilize the spun fiber (crystallization), the formation of the polymer–fiber composite, the selection of the proper gas-foaming processing parameter and the final leaching in water.
Scaffolds with Tubular/Isotropic Bi-modal Pore Structures by Gas Foaming and Fiber Templating / DI MAIO, Ernesto; A., Salerno; S., Iannace. - In: MATERIALS LETTERS. - ISSN 0167-577X. - 93:(2013), pp. 157-160. [10.1016/j.matlet.2012.11.036]
Scaffolds with Tubular/Isotropic Bi-modal Pore Structures by Gas Foaming and Fiber Templating
DI MAIO, ERNESTO;
2013
Abstract
The aim of this study was to engineer a scaffold for tissue engineering with double shape pore architecture, with tubular and isotropic pores. A novel method is herein proposed, based on the combination of gas foaming and fiber templating. In particular, the tubular pores have been obtained by leaching of melt–spun saccharide fibers (cottoncandy) within CO2-foamed poly(e-caprolactone). The optimization of the scaffold has been conducted via the selection of the proper saccharide, its thermal treatment to stabilize the spun fiber (crystallization), the formation of the polymer–fiber composite, the selection of the proper gas-foaming processing parameter and the final leaching in water.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
