Diarylheptanoids (DHs) are an unusual class of natural products composed of two aromatic rings linked by a C7 chain. They showed interesting biological activities, including leishmanicidal and antiprotozoal,1 antitumor, antioxidant, anti-ischemic, anti-inflammatory, and inhibitory against NO production. In addition to the more common linear DHs, there is a smaller number of cyclic DHs, formed from the linear type by phenolic oxidative coupling.3 The isolation and structural elucidation of two new cyclic diarylheptanoids (the diaryl ether 1 and the diphenyl 2) from the marine sponge Tedania ignis will be presented. Compound 1, but not compound 2, inhibits NO production. The conformational equilibria of the two molecules, which made their apparently simple structure elucidation a challenging process, will be discussed.

Conformational studies of tedarenes, two cyclic diarylheptanoids from the sponge Tedania ignis

COSTANTINO, VALERIA;MANGONI, ALFONSO;IANARO, ANGELA;PANZA, ELISABETTA
2010

Abstract

Diarylheptanoids (DHs) are an unusual class of natural products composed of two aromatic rings linked by a C7 chain. They showed interesting biological activities, including leishmanicidal and antiprotozoal,1 antitumor, antioxidant, anti-ischemic, anti-inflammatory, and inhibitory against NO production. In addition to the more common linear DHs, there is a smaller number of cyclic DHs, formed from the linear type by phenolic oxidative coupling.3 The isolation and structural elucidation of two new cyclic diarylheptanoids (the diaryl ether 1 and the diphenyl 2) from the marine sponge Tedania ignis will be presented. Compound 1, but not compound 2, inhibits NO production. The conformational equilibria of the two molecules, which made their apparently simple structure elucidation a challenging process, will be discussed.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/517568
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact