Complex polysubstituted alkyl sulfates have been isolated from ascidians; a remarkable example is turbinamide, a bioactive metabolite isolated in our laboratory from Sidnyum turbinatum. This molecule demonstrated a strong and selective cytotoxic effect against neuronal rather than immune system cells. We have indeed isolated two new sulphated compounds (1 and 2) from another collection of S. turbinatum; as well as two new molecules (3 and 4) from two different Mediterranean ascidians (Sidnyum elegans and Ciona edwardsii). Their structural analogy with turbinamide allowed evaluating the influence of slight structural modifications on the activity.
Polysubstituted alkyl sulfates with antiproliferative activity from different species of Mediterranean ascidians / Aiello, Anna; Fattorusso, Ernesto; Imperatore, Concetta; Luciano, Paolo; Menna, Marialuisa; Vitalone, Rocco; Irace, Carlo; Santamaria, Rita. - STAMPA. - (2009), pp. 308-308. (Intervento presentato al convegno XXIII Congresso Nazionale della Società Chimica Italiana tenutosi a Sorrento nel 5-10 luglio 2009).
Polysubstituted alkyl sulfates with antiproliferative activity from different species of Mediterranean ascidians
AIELLO, ANNA;FATTORUSSO, ERNESTO;IMPERATORE, CONCETTA;LUCIANO, PAOLO;MENNA, MARIALUISA;VITALONE, ROCCO;IRACE, CARLO;SANTAMARIA, RITA
2009
Abstract
Complex polysubstituted alkyl sulfates have been isolated from ascidians; a remarkable example is turbinamide, a bioactive metabolite isolated in our laboratory from Sidnyum turbinatum. This molecule demonstrated a strong and selective cytotoxic effect against neuronal rather than immune system cells. We have indeed isolated two new sulphated compounds (1 and 2) from another collection of S. turbinatum; as well as two new molecules (3 and 4) from two different Mediterranean ascidians (Sidnyum elegans and Ciona edwardsii). Their structural analogy with turbinamide allowed evaluating the influence of slight structural modifications on the activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
