The present invention relates to supramolecular aggregates (liposomes, vesicles, or micelles) for target selective drug delivery; more specifically it relates to supramolecular aggregates derivatized with Neurotensin peptide in a branched form and filled, in their inner compartment or in the phospholipid bilayer, with a pharmaceutical active principle such as a cytotoxic chemotherapeutic drug. The aggregates are selectively driven by the exposed branched bioactive peptides to specific receptors overexpressed in malignant cells.
SUPRAMOLECULAR AGGREGATES AS DRUG CARRIERS ON CELL EXPRESSING RECEPTORS FOR BRANCHED NEUROTENSIN / Tesauro, Diego; Accardo, Antonella; Morelli, Giancarlo; Pedone, C.; Falciani, C.; Pini, A.; Bracci, L.. - (2010).
SUPRAMOLECULAR AGGREGATES AS DRUG CARRIERS ON CELL EXPRESSING RECEPTORS FOR BRANCHED NEUROTENSIN
TESAURO, DIEGO;ACCARDO, ANTONELLA;MORELLI, GIANCARLO;
2010
Abstract
The present invention relates to supramolecular aggregates (liposomes, vesicles, or micelles) for target selective drug delivery; more specifically it relates to supramolecular aggregates derivatized with Neurotensin peptide in a branched form and filled, in their inner compartment or in the phospholipid bilayer, with a pharmaceutical active principle such as a cytotoxic chemotherapeutic drug. The aggregates are selectively driven by the exposed branched bioactive peptides to specific receptors overexpressed in malignant cells.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
