Oligonucleotides with a 3'-3' inversion of polarity and containing an acridine group attached to nucleotide base flanking the 3'-3' phosphodiester bon have been synthesized, characterized and used as third strand in alternate triple helix formation. CD melting studies and molecular mechanics calculations have been carried out to investigate these triplex structures.
Oligonucleotides Containing an Acridine Group Covalently Bonded to the Nucleotide Flanking the 3′-3′ Phosphodiester Junction for Alternate Strand Triple Helix Formation / Catalanotti, Bruno; Fattorusso, Caterina; Mayol, Luciano; Oliviero, Giorgia; Piccialli, Gennaro; Varra, Michela. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - STAMPA. - 22:(2003), pp. 1069-1071. [10.1081/NCN-120022738]
Oligonucleotides Containing an Acridine Group Covalently Bonded to the Nucleotide Flanking the 3′-3′ Phosphodiester Junction for Alternate Strand Triple Helix Formation
CATALANOTTI, BRUNO;FATTORUSSO, CATERINA;MAYOL, LUCIANO;OLIVIERO, GIORGIA
;PICCIALLI, GENNARO;VARRA, MICHELA
2003
Abstract
Oligonucleotides with a 3'-3' inversion of polarity and containing an acridine group attached to nucleotide base flanking the 3'-3' phosphodiester bon have been synthesized, characterized and used as third strand in alternate triple helix formation. CD melting studies and molecular mechanics calculations have been carried out to investigate these triplex structures.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
