Haemostatic alterations in dogs naturally infected by ehrlichiosis and/or leishmaniasis were studied. Platelet count, ADP and collagen-induced platelet aggregation, prothrombin time, activated partial thromboplastin time (APTT) and plasma fibrinogen concentration were measured. An evident reduction of platelet aggregation response was shown for Leishmania– Ehrlichia co-infected dogs where platelet aggregation was lower in comparison with control and leishmaniotic dogs (ADP and collagen, P £ 0.01) and ehrlichiotic dogs (ADP 10 and 7.5 lm, P £ 0.05). Moreover, a significant increase in APTT as well as a reduction of the albumin/globulin rate (A/ G) for leishmaniotic and co-infected dogs versus control and ehrlichiotic dogs was detected. The hypothesis of a synergism between leishmaniosis and ehrlichiosis in altering platelet function by different pathways is discussed.
Platelet Aggregation and Haemostatic Response in Dogs Naturally Co-infected by Leishmania infantum and Ehrlichia canis / Cortese, Laura; Pelagalli, Alessandra; Piantedosi, Diego; Mastellone, Vincenzo; A., Manco; Lombardi, Pietro; Ciaramella, Paolo; Avallone, Luigi. - In: JOURNAL OF VETERINARY MEDICINE. SERIES A. - ISSN 1439-0442. - STAMPA. - 53:(2006), pp. 546-548.
Platelet Aggregation and Haemostatic Response in Dogs Naturally Co-infected by Leishmania infantum and Ehrlichia canis
CORTESE, LAURA;PELAGALLI, ALESSANDRA;PIANTEDOSI, DIEGO;MASTELLONE, VINCENZO;LOMBARDI, PIETRO;CIARAMELLA, PAOLO;AVALLONE, LUIGI
2006
Abstract
Haemostatic alterations in dogs naturally infected by ehrlichiosis and/or leishmaniasis were studied. Platelet count, ADP and collagen-induced platelet aggregation, prothrombin time, activated partial thromboplastin time (APTT) and plasma fibrinogen concentration were measured. An evident reduction of platelet aggregation response was shown for Leishmania– Ehrlichia co-infected dogs where platelet aggregation was lower in comparison with control and leishmaniotic dogs (ADP and collagen, P £ 0.01) and ehrlichiotic dogs (ADP 10 and 7.5 lm, P £ 0.05). Moreover, a significant increase in APTT as well as a reduction of the albumin/globulin rate (A/ G) for leishmaniotic and co-infected dogs versus control and ehrlichiotic dogs was detected. The hypothesis of a synergism between leishmaniosis and ehrlichiosis in altering platelet function by different pathways is discussed.File | Dimensione | Formato | |
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