Pertussis immunization in HIV-1-infected infants: a model to assess the effects of repeated T cell-dependent antigen administrations on HIV-1 progression. Italian Register for HIV infection in children.

Tovo, Pa; de Martino, M; Gabiano, C; Galli, L; Osimani, P; De Mattia, D; Zizzadoro, P; Ruggeri, M; Masi, M; Dell'Erba, G; Lanari, M; Bosi, I; Chiriacò, P. G.; Duse, M; Crispino, P; Soresina, M. R.; Bresciani, E; Battisti, L; Pintor, C; Chiappe, F; Belloni, M; Loriano, D; Ibba, P; Berrino, R; Nasi, C; Sticca, M; Palmieri, M; Anastasio, E; Bezzi, T; Vierucci, A; Guarino Amato, A; Farina, S; Cecchi, M. T.; De Maria, A; Fioredda, F; Donelli, E; Marazzi, M. G.; Pontali, E; Forni, G. L.; Cosso, Ed; Gotta, C; Lobello, D; Tondo, U; Micheletti, E; Ruggeri, C; Plebani, A; Pinzani, R; Salvini, F; Marchisio, P; Esposito, E; Massironi, E; Zuccotti, G. V.; Riva, E; Gamboni, A; Ferraris, G; Rancilio, L; Vegni, C; Altobelli, R; Lipreri, R; Conio, S; Lizzoli, F; Gambaretto, G; Cellini, M; Pignata, C; Pozzi, N; Guarino, Alfredo; Romano, A; Todeschini, A; Giaquinto, C; Ruga, E. M.; Rampon, O; Consolini, R; Palla, G; Legitimo, A; Benaglia, G; Caselli, D; Maccabruni, A; Pacati, I; Antonellini, A; Metri, A; Magnani, C; Falconieri, P; Fundarò, C; Genovese, O; Rendeli, C; Stegagno, M; Castelli Gattianra, G; Bernardi, S; Cancrini, C; Timpano, C; Anzidei, G; Marchilli, M. R.; Catania, S; Ogana, C; Mazza, A; Di Palma, A; Scolfaro, C; Riva, C; Palomba, E; Salvatore, C.

Several data evidence that HIV-1 replication may increase in temporal association with immunizations, raising concerns on potential negative effects of vaccinations on HIV-1 progression. Among patients prospectively followed by the "Italian Register for HIV infection in children", we evaluated, using the Cox-Mantel method, conditional probabilities of progressing to CDC clinical categories 'B' or 'C', and immunological categories '2' or '3' in 88 children immunized against pertussis and 244 non-immunized. No selection criteria were followed in vaccinating children. No significant differences were observed between the two groups. The lack of a significant impact on clinical and immunological deterioration by the repeated administrations of a T cell-dependent vaccine endorses the current recommendations for routine immunizations in HIV-1-infected children

Pertussis immunization in HIV-1-infected infants: a model to assess the effects of repeated T cell-dependent antigen administrations on HIV-1 progression. Italian Register for HIV infection in children / Tovo, Pa; de Martino, M; Gabiano, C; Galli, L; Osimani, P; De Mattia, D; Zizzadoro, P; Ruggeri, M; Masi, M; Dell'Erba, G; Lanari, M; Bosi, I; Chiriacò, P. G.; Duse, M; Crispino, P; Soresina, M. R.; Bresciani, E; Battisti, L; Pintor, C; Chiappe, F; Belloni, M; Loriano, D; Ibba, P; Berrino, R; Nasi, C; Sticca, M; Palmieri, M; Anastasio, E; Bezzi, T; Vierucci, A; Guarino Amato, A; Farina, S; Cecchi, M. T.; De Maria, A; Fioredda, F; Donelli, E; Marazzi, M. G.; Pontali, E; Forni, G. L.; Cosso, Ed; Gotta, C; Lobello, D; Tondo, U; Micheletti, E; Ruggeri, C; Plebani, A; Pinzani, R; Salvini, F; Marchisio, P; Esposito, E; Massironi, E; Zuccotti, G. V.; Riva, E; Gamboni, A; Ferraris, G; Rancilio, L; Vegni, C; Altobelli, R; Lipreri, R; Conio, S; Lizzoli, F; Gambaretto, G; Cellini, M; Pignata, C; Pozzi, N; Guarino, Alfredo; Romano, A; Todeschini, A; Giaquinto, C; Ruga, E. M.; Rampon, O; Consolini, R; Palla, G; Legitimo, A; Benaglia, G; Caselli, D; Maccabruni, A; Pacati, I; Antonellini, A; Metri, A; Magnani, C; Falconieri, P; Fundarò, C; Genovese, O; Rendeli, C; Stegagno, M; Castelli Gattianra, G; Bernardi, S; Cancrini, C; Timpano, C; Anzidei, G; Marchilli, M. R.; Catania, S; Ogana, C; Mazza, A; Di Palma, A; Scolfaro, C; Riva, C; Palomba, E; Salvatore, C.. - In: VACCINE. - ISSN 0264-410X. - STAMPA. - 18:13(2000), pp. 1203-1209.