Several data evidence that HIV-1 replication may increase in temporal association with immunizations, raising concerns on potential negative effects of vaccinations on HIV-1 progression. Among patients prospectively followed by the "Italian Register for HIV infection in children", we evaluated, using the Cox-Mantel method, conditional probabilities of progressing to CDC clinical categories 'B' or 'C', and immunological categories '2' or '3' in 88 children immunized against pertussis and 244 non-immunized. No selection criteria were followed in vaccinating children. No significant differences were observed between the two groups. The lack of a significant impact on clinical and immunological deterioration by the repeated administrations of a T cell-dependent vaccine endorses the current recommendations for routine immunizations in HIV-1-infected children

Pertussis immunization in HIV-1-infected infants: a model to assess the effects of repeated T cell-dependent antigen administrations on HIV-1 progression. Italian Register for HIV infection in children / Tovo, P.a., de Martino, M., Gabiano, C., Galli, L., Osimani, P., De Mattia, D., Zizzadoro, P., Ruggeri, M., Masi, M., Dell'Erba, G., Lanari, M., Bosi, I., Chiriacò, P.G., Duse, M., Crispino, P., Soresina, M.R., Bresciani, E., Battisti, L., Pintor, C., Chiappe, F., et al.. - In: VACCINE. - ISSN 0264-410X. - STAMPA. - 18:13(2000), pp. 1203-1209.

Pertussis immunization in HIV-1-infected infants: a model to assess the effects of repeated T cell-dependent antigen administrations on HIV-1 progression. Italian Register for HIV infection in children.

Pignata C;GUARINO, ALFREDO;
2000

Abstract

Several data evidence that HIV-1 replication may increase in temporal association with immunizations, raising concerns on potential negative effects of vaccinations on HIV-1 progression. Among patients prospectively followed by the "Italian Register for HIV infection in children", we evaluated, using the Cox-Mantel method, conditional probabilities of progressing to CDC clinical categories 'B' or 'C', and immunological categories '2' or '3' in 88 children immunized against pertussis and 244 non-immunized. No selection criteria were followed in vaccinating children. No significant differences were observed between the two groups. The lack of a significant impact on clinical and immunological deterioration by the repeated administrations of a T cell-dependent vaccine endorses the current recommendations for routine immunizations in HIV-1-infected children
2000
Pertussis immunization in HIV-1-infected infants: a model to assess the effects of repeated T cell-dependent antigen administrations on HIV-1 progression. Italian Register for HIV infection in children / Tovo, P.a., de Martino, M., Gabiano, C., Galli, L., Osimani, P., De Mattia, D., Zizzadoro, P., Ruggeri, M., Masi, M., Dell'Erba, G., Lanari, M., Bosi, I., Chiriacò, P.G., Duse, M., Crispino, P., Soresina, M.R., Bresciani, E., Battisti, L., Pintor, C., Chiappe, F., et al.. - In: VACCINE. - ISSN 0264-410X. - STAMPA. - 18:13(2000), pp. 1203-1209.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/514508
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