The substitution of a hydroxyl group by a fluorine atom in a potential drug is an efficient reaction that can, in principle, improve its pharmacological properties. Herein, the synthesis of the novel compound 5′-fluoro- 5′-deoxyacadesine (5′-F-AICAR), a strict analogue of AICAR that cannot be 5′-phosphorylated to ZMP by cellular kinases, is reported. © 2012 by the authors.
A Facile Synthesis of 5'-Fluoro-5'-deoxyacadesine (5'-F-AICAR): A Novel Non-phosphorylable AICAR Analogue / D'Errico, Stefano; Oliviero, Giorgia; Borbone, Nicola; Amato, Jussara; D'Alonzo, Daniele; Piccialli, Vincenzo; Mayol, Luciano; Piccialli, Gennaro. - In: MOLECULES. - ISSN 1420-3049. - 17:11(2012), pp. 13036-13044. [10.3390/molecules171113036]
A Facile Synthesis of 5'-Fluoro-5'-deoxyacadesine (5'-F-AICAR): A Novel Non-phosphorylable AICAR Analogue
Stefano D’Errico;OLIVIERO, GIORGIA;BORBONE, NICOLA;AMATO, JUSSARA;Daniele D’Alonzo;PICCIALLI, VINCENZO;MAYOL, LUCIANO;PICCIALLI, GENNARO
2012
Abstract
The substitution of a hydroxyl group by a fluorine atom in a potential drug is an efficient reaction that can, in principle, improve its pharmacological properties. Herein, the synthesis of the novel compound 5′-fluoro- 5′-deoxyacadesine (5′-F-AICAR), a strict analogue of AICAR that cannot be 5′-phosphorylated to ZMP by cellular kinases, is reported. © 2012 by the authors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
