The substitution of a hydroxyl group by a fluorine atom in a potential drug is an efficient reaction that can, in principle, improve its pharmacological properties. Herein, the synthesis of the novel compound 5′-fluoro- 5′-deoxyacadesine (5′-F-AICAR), a strict analogue of AICAR that cannot be 5′-phosphorylated to ZMP by cellular kinases, is reported. © 2012 by the authors.

A Facile Synthesis of 5'-Fluoro-5'-deoxyacadesine (5'-F-AICAR): A Novel Non-phosphorylable AICAR Analogue

Stefano D’Errico;OLIVIERO, GIORGIA;BORBONE, NICOLA;AMATO, JUSSARA;Daniele D’Alonzo;PICCIALLI, VINCENZO;MAYOL, LUCIANO;PICCIALLI, GENNARO
2012

Abstract

The substitution of a hydroxyl group by a fluorine atom in a potential drug is an efficient reaction that can, in principle, improve its pharmacological properties. Herein, the synthesis of the novel compound 5′-fluoro- 5′-deoxyacadesine (5′-F-AICAR), a strict analogue of AICAR that cannot be 5′-phosphorylated to ZMP by cellular kinases, is reported. © 2012 by the authors.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/513569
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